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530 Understanding Strengths and Weaknesses of Clinical Research Operations in Regional Settings

Published online by Cambridge University Press:  03 April 2024

Allison Lambert
University of Washington, Institute of Translational Health Sciences Providence Medical Research Center
Laurie Hassell
University of Washington, Institute of Translational Health Sciences
James Probus
University of Washington, Institute of Translational Health Sciences
Kiet Pham
University of Washington, School Psychology
Monica Zigman-Suchsland
University of Washington, Department of Family Medicine
Jamie M. Besel
Billings Clinic Elizabeth Brewer, Kootenai Health
Dillon Van Rensburg
University of Washington, Institute of Translational Health Sciences
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OBJECTIVES/GOALS: An environmental scansoughtto understand research processes, areas for improvement, and opportunities for collaborative quality improvement (QI)across the Northwest Participant and Clinical Interactions Network (NW PCI). METHODS/STUDY POPULATION: NW PCI site champions were invited for semi-structured single and group Zoom-based interviews. Interviewers asked participants about local research processes, strengths and weaknesses, existing infrastructure to support QI, and interest in collaborative QI across the Network. Audio transcripts were coded using Dedoose and analyzed with deductive and inductive coding. RESULTS/ANTICIPATED RESULTS: Between February and April 2023, 10 interviews collected data from 7 research decision makers and 7 staff members across 7 sites. Most participants (n=13, 92%) agreed the diagram shown during the interview was representative of the local process. Organizations consistently identified strengths and weaknesses within the domains of study start-up, recruitment, budgets, and compliance. QI infrastructure was inconsistent (n=5, 36%) and all (n=14, 100%) saw potential for success in multisite QI initiatives to enhance efficiency. DISCUSSION/SIGNIFICANCE: NW PCI sites use similar processes, share common strengths and weaknesses, and universally reported interest in collaborating on QI. Study startup was reported as both a strength and weakness within the same organization, requiring unpacking of key elements before pursuing QI initiatives.

Research Management, Operations, and Administration
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work.
© The Author(s), 2024. The Association for Clinical and Translational Science