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Detection of natural selection by methods based on models of the behaviour of neutral alleles

Published online by Cambridge University Press:  31 July 2008

B. K. Averill
Affiliation:
Department of Human Genetics, University of Newcastle upon Tyne

Summary

The allele frequency data of artificial populations were examined by several methods which test whether various configurations of allele frequencies are the result of drift or selection. Although no genotypic selective differences were included in these populations the methods indicated that selection was operating in some instances; hence the models are not reliable. Distinguishing between the actions of drift and selection would be facilitated if data for many loci were included, so that a notion of the variance of the genetic variation measure could be obtained.

Type
Research Article
Copyright
Copyright © 1980, Cambridge University Press

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References

Averill, B.K. (1977) Simulation Studies in the Population Biology of Small Groups. PhD thesis, University of Cambridge.Google Scholar
Coale, A.J. & Demeny, P. (1966) Regional Model Life Tables and Stable Populations. Princeton University Pess, Princeton, NJ.Google Scholar
Ewens, W.J. (1972) The sampling theory of selectively neutral alleles. Theoret. Pop. Biol. 3, 87.CrossRefGoogle ScholarPubMed
Ewens, W.J. (1977) Population genetics theory in relation to the neutralist-selectionist controversy. In: Advances in Human Genetics, 8, 67. Edited by Harris, H. & Hirschhorn, K.. Plenum, New York.Google Scholar
Ewens, W.J. & Gillespie, J.H. (1974) Some simulation results for the neutral allele model, with interpretations. Theoret. Pop. Biol. 6, 135.CrossRefGoogle ScholarPubMed
Johnson, G. & Feldman, M. (1973) On the hypothesis that enzyme alleles are selectively neutral. 1. The evenness of allele frequency distribution. Theoret. Pop. Biol. 4, 209.CrossRefGoogle Scholar
Karlin, S. & MacGregor, J. (1972) Addendum to a paper of W. J. Ewens. Theoret. Pop. Biol. 3, 113.CrossRefGoogle Scholar
Lewontin, R.C. & Krakauer, J. (1973) Distribution of gene frequency as a test of the theory of the selective neutrality of polymorphisms. Genetics, 74, 175.CrossRefGoogle ScholarPubMed
MacCluer, J.W. (1967) Monte Carlo methods in human population genetics: a computer model incorporating age-specific birth and death rates. Am. J. hum. Genet. 19, 303.Google ScholarPubMed
MacCluer, J.W. (1974) Monte Carlo simulation: the effects of migration on some measures of genetic distance. In: Genetic Distance, p. 77. Edited by Crow, J. F., Denniston, C. & O'Shea, P.. Plenum, New York.CrossRefGoogle Scholar
Nei, M. (1972) Genetic distance between populations. Am. Nat. 106, 283.CrossRefGoogle Scholar
Nei, M. & Imaizumi, Y. (1966) Genetic structure of human populations. II. Differentiation of blood group gene frequencies among isolated populations. Heredity, 21, 183.CrossRefGoogle ScholarPubMed
Nei, M. & Maruyama, T. (1975) Lewontin-Krakauer test for neutral genes. Genetics, 80, 395.CrossRefGoogle ScholarPubMed
Perrin, E.B. & Sheps, M.C. (1964) Human reproduction: a stochastic process. Biometrics, 20, 28.CrossRefGoogle Scholar
Roberts, D.F. & Mohan, M. (1976) History, demography and genetics: the Fiji experience and its evolutionary implications. In: The Demographic Evolution of Human Populations, p. 117. Edited by Ward, R. H. & Weiss, K. M.. Academic Press, London.Google Scholar
Robertson, A. (1975a) Remarks on the Lewontin-Krakauer test. Genetics, 80, 396.CrossRefGoogle ScholarPubMed
Robertson, A. (1975b) Gene frequency distribution as a test of selective neutrality. Genetics, 81, 775.CrossRefGoogle ScholarPubMed
Skolnick, M. & Cannings, C. (1973) Simulation of small human populations. In: Computer Simulation in Human Population Studies, p. 167. Edited by Dyke, B. & MacCluer, J. W.. Academic Press, London.Google Scholar
Stewart, P.M. (1976) Variability in the amount of heterozygosity maintained by neutral mutations. Theoret. Pop. Biol. 9, 188.CrossRefGoogle ScholarPubMed
Thompson, E.A. (1972) Rates of change of world ABO blood group frequencies. Ann. hum. Genet. 35, 357.CrossRefGoogle ScholarPubMed
Wright, S. (1949) Population structure in evolution. Proc. Am. Phil. Soc. 93, 471.Google ScholarPubMed
Wright, S. (1965) The interpretation of population structure by F statistics with special regard to systems of mating. Evolution, 19, 395.CrossRefGoogle Scholar