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Development of controlled trials in preventive and therapeutic medicine

Published online by Cambridge University Press:  31 July 2008

Richard Doll
Affiliation:
ICRF Cancer Studies Unit, Radcliffe Infirmary, Oxford

Abstract

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Type
Darwin Lecture
Copyright
Copyright © Cambridge University Press 1991

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References

Armitage, P. (1982) The role of randomisation in clinical trials. Statist. Med. 1, 345.CrossRefGoogle Scholar
Chalmers, T. C, Matta, R. J., Smith, H. & Kunzler, A. M. (1977) Evidence favouring the use of anticoagulants in the hospital phase of acute myocardial infarction. New Engl. J. Med. 297, 1091.CrossRefGoogle Scholar
Chandler, J. (1662) Oriatrike or Physic Refined, by van Helmont, J. B. (translation). Lodowick Loyd, London. Cited by Debus, A. G. (1968) In: The Chemical Dream of the Renaissance, p. 27. Heffer, Cambridge.Google Scholar
Cochran, W. G. (1954) Some methods for strengthening the common x2 tests. Biometrics, 10, 417.CrossRefGoogle Scholar
Cox, D. R. (1966) Some procedures connected with the qualitative response curve. In: Festschrift for J. Neyman: Research Papers in Statistics, pp. 5571. Edited by David, F. N.. Wiley, New York.Google Scholar
Cox, D. R. (1972) Regression models and life-tables. J. Roy. Statist. Soc. B34, 187.Google Scholar
Doll, R. (1982) Clinical trials: retrospect and prospect. Statist. Med. 1, 337.CrossRefGoogle ScholarPubMed
Early Breast Cancer Trialists' Collaborative Group (1988) Effects of adjuvant tamoxifen and of cytotoxic therapy on mortality in early breast cancer. New Engl. J. Med. 319, 1681.CrossRefGoogle Scholar
Editorial (1980) Aspirin after myocardial infarction. Lancet, i, 1172.Google Scholar
Fibiger, J. (1898) Om serumbehandlung af Difteri. Hospitalstidende, 6, 309, 337.Google Scholar
Fisher, R. A. (1926) The arrangement of field experiments. J. Min. Agric. 33, 503.Google Scholar
Fisher, R. A. (1935) The Design of Experiments. Oliver & Boyd, Edinburgh.Google Scholar
Gehan, E. A. & Freireich, E. J. (1974) Non-randomized controls in cancer clinical trials. New Engl.J. Med. 290, 198.CrossRefGoogle ScholarPubMed
GISSI (1986) Effectiveness of intravenous thrombolytic therapy in acute myocardial infarction. Lancet, i, 397.Google Scholar
Hill, A. B. (1937) Principles of Medical Statistics. Lancet, London.Google Scholar
Hill, A. B. (1963) Medical ethics and controlled trials. Br. med. J., 1, 1043.CrossRefGoogle ScholarPubMed
Hill, A. B. (1990) Memories of the British Streptomycin Trial in Tuberculosis. Controlled clin.Trials, 11, 77.CrossRefGoogle ScholarPubMed
ISIS-2 Collaborative Group (1988)Randimised trial intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction. Lancet, ii, 349.Google Scholar
Mantel, N. (1966) Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemotherapy Rep. 50, 163.Google ScholarPubMed
Mantel, N. & Haenszel, W. (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J. natn. Cancer Inst. 22, 719.Google Scholar
Medical Research Council (1986) Improvement in treatment for children with acute lymphoblastic leukaemia. The Medical Research Council UKALL Trials, 1972–84. Lancet, i, 408.Google Scholar
Medical Research Council Streptomycin in Tuberculosis Trials Committee (1948) Streptomycin treatment for pulmonary tuberculosis. Br. med. J. 2, 769.CrossRefGoogle Scholar
Medical Research Council Tuberculosis Chemotherapy Trials Committee (1952) The treatment of pulmonary tuberculosis with isoniazid. Br. med. J. 2, 735.CrossRefGoogle Scholar
Medical Research Council Whooping-Cough Immunization Committee (1951) The prevention of whooping-cough by vaccination. Br. med. J. 2, 1463.Google Scholar
Passamani, E. R. (1982) Nitroprusside in myocardial infarction. New Engl. J. Med. 306, 1168.CrossRefGoogle ScholarPubMed
Pearson, K. (1904) Report on certain enteric fever inoculation statistics. Br. med. J. 2, 1243.Google Scholar
Peto, R. & Peto, J. (1972) Asymptomatically efficient rank invariant test procedures (with discussion). J. Roy. statist. Soc. A135, 185.CrossRefGoogle Scholar
Peto, R., Pike, M. C., Armitage, P., Breslow, N. E., Cox, D. R., Howard, S. V., Mantel, N., McPherson, K., Peto, J. & Smith, P. G. (1976) Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design. Br. J. Cancer, 34, 585.CrossRefGoogle ScholarPubMed
Peto, R., Pike, M. C., Armitage, P., Breslow, N. E., Cox, D. R., Howard, S. V., Mantel, N., McPherson, K., Peto, J. & Smith, P. G. (1977) Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples. Br. J. Cancer, 35, 1.CrossRefGoogle ScholarPubMed
Prichard, B. N. C., Dickinson, D. J., Alleyne, G. A. O., Hurst, P., Hill, I. D., Rosenheim, M. L. & Laurence, D. R. (1963) Effect of pronethalol in angina pectoris. Br. med. J. 2, 1226.Google ScholarPubMed
Quin, C. A., Mason, R. M. & Knowelden, J. (1950) Clinical assessment of rapidly acting agents in rheumatoid arthritis. Br. med. J. 2, 810.CrossRefGoogle ScholarPubMed
Truelove, S. C. & Witts, L. J. (1955) Cortisone in ulcerative colitis: final report of a therapeutic trial. Br. med. J. 2, 1041.CrossRefGoogle ScholarPubMed
Wilson, C., Pollock, M. R. & Harris, A. D. (1946) Diet in the treatment of infectious hepatitis. Lancet, i, 881.CrossRefGoogle Scholar
Yusuf, S., Collins, R. & Peto, R. (1984) Why do we need some large simple randomised trials? Statist. Med. 3, 409.CrossRefGoogle Scholar
Yusuf, S., Collins, R., Peto, R., Furberg, C., Stampfers, M. J., Goldhaber, S. Z. & Hennekens, C. H. (1985a) Intravenous and intracoronary fibrinolytic therapy in acute myocardial infarction: overview of results on mortality, reinfarction and side effects from 33 randomised controlled trials. Eur. Heart J. 6, 556.CrossRefGoogle Scholar
Yusuf, S., Peto, R., Lewis, J., Collins, R. & Sleight, P. (1985b) Beta-blockade during and after myocardial infarction: an overview of the randomized trials. Prog. Cardiovasc. Dis. 27, 335.CrossRefGoogle ScholarPubMed

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