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The host environment determines strain-specific differences in the timing of skeletal muscle regeneration: cross-transplantation studies between SJL/J and BALB/c mice

Published online by Cambridge University Press:  01 November 1997

PETER ROBERTS ,
JOHN K. McGEACHIE  and
MIRANDA D. GROUNDS
PETER ROBERTS
Affiliation:
Department of Human Biology, Edith Cowan University
JOHN K. McGEACHIE
Affiliation:
Department of Anatomy and Human Biology, University of Western Australia
MIRANDA D. GROUNDS
Affiliation:
Department of Anatomy and Human Biology, University of Western Australia
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Abstract

The difference in the timing of the regeneration process of skeletal muscle between SJL/J and BALB/c mice was investigated using grafts of whole skeletal muscle (both autografts and allografts). Histological, autoradiographic and immunohistochemical techniques were used in the investigation. Infiltration of leucocytes into autografts, numbers of desmin-positive myogenic cells and myotube formation were all more advanced in the SJL/J compared with BALB/c mice. Furthermore, autoradiographic evidence showed that myoblasts in the SJL/J autografts were synthesising DNA 12 h earlier than myoblasts in BALB/c autografts. In allografts, where SJL/J host mice received BALB/c grafts, and vice versa, leucocyte infiltration and myotube formation occurred earlier in the BALB/c muscles grafted into SJL/J hosts, than in the reverse situation with BALB/c hosts. The results show that, at least for whole muscle grafts, it is the host environment which determines the speed and outcome of the regenerative process.

Keywords

Muscle autografts and allograftsleucocytesmyotubesdesminautoradiography
Type
Research Article
Information
The Journal of Anatomy , Volume 191 , Issue 4 , November 1997 , pp. 585 - 594
Copyright
© Anatomical Society of Great Britain and Ireland 1997

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