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The response of plasma minerals, free fatty acids and glucose to adrenaline and cortisol infusion in sheep

Published online by Cambridge University Press:  27 March 2009

Sarah C. Bolton
Affiliation:
Department of Agricultural Biochemistry and Nutrition, The University, Newcastle upon Tyne, NE1 7RU
T. E. C. Weekes
Affiliation:
Department of Agricultural Biochemistry and Nutrition, The University, Newcastle upon Tyne, NE1 7RU

Summary

Adrenaline was infused at three rates, 40, 15 or 3 μ/kg/h, in normal sheep and in sheep rendered hypercortisolaemic by infusion of cortisol at 150 μg/kg/h. In both normal and hypercortisolaemic animals, plasma concentrations of glucose and free fatty acids were increased by adrenaline treatment; plasma phosphate decreased with all treatments; plasma magnesium and potassium decreased on infusion of adrenaline at 40 or 15, but not at 3 μg/kg/h; plasma calcium decreased only on infusion of adrenaline in hypercortisolaemic animals, and plasma sodium concentration was unaffected by treatment.

Induction of a degree of lipolysis likely to occur in the field was not associated with a marked decrease in plasma magnesium.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1986

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References

REFERENCES

Bassett, J. M. & Hinks, N. T. (1969). Micropunoture determination of corticosteroids in ovine peripheral plasma: effects of venepuncture, corticotrophin, insulin and glucose. Journal of Endocrinology 44, 387403.CrossRefGoogle Scholar
Berkenbosch, F., Vermes, I., Binnekade, R. & Tilders, F. J. H. (1981). Beta-adrenergic stimulation induces an increase of the plasma levels of immunoreactive α-MSH, β-endorphin, ACTH and of corticosterone. Life Sciences 29, 22492256.CrossRefGoogle ScholarPubMed
Bloom, S. R., Edwards, A. V., Hardy, R. N., Malinowska, K. W. & Silver, M. (1975). Endocrine responses to hypoglycaemia in the young calf. Journal of Physiology 244, 783803.CrossRefGoogle ScholarPubMed
Care, A. D. & Ross, D. B. (1963). The role of the adrenal cortex in magnesium homeostasis and in the aetiology of hypomagnesaemia. Research in Veterinary Science 4, 2438.CrossRefGoogle Scholar
Crone, C. (1965). The secretion of adrenal medullary hormones during hypoglycaemia in intact decerebrate and spinal sheep. Acta Physiologica Scandinavica 63, 213224.CrossRefGoogle ScholarPubMed
Deavers, D. R. & Musacchia, X. J. (1979). The function of glucocorticoids in thermogenesis. Federation Proceedings 38, 21772181.Google ScholarPubMed
Elliott, D. A. & Rizack, M. A. (1974). Epinephrine and adrenocorticotrophic hormone-stimulated magnesium accumulation in adipoeytes and their plasma membranes. Journal of Biological Chemistry 249, 39853990.CrossRefGoogle Scholar
Espiner, E. A., Lun, S. & Hart, D. S. (1978). Role of ACTH, angiotensin and potassium in stress-induced aldosterone secretion. Journal of Steroid Biochemistry 9, 109113.CrossRefGoogle ScholarPubMed
Fischer, J. A., Blum, J. W. & Binswanger, V. (1973). Acute parathyroid hormone response to epinephrine in vivo. Journal of Clinical Investigation 52, 24342440.CrossRefGoogle ScholarPubMed
Flink, E. B., Shane, S. R., Scobbo, R. R., Blehschmidt, N. G. & McDowell, P. (1979). Relationship of free fatty acids and magnesium in ethanol withdrawal in dogs. Metabolism 28, 853865.CrossRefGoogle ScholarPubMed
Gomorri, G. (1942). A modification of the colorimetric phosphorus determination for use with the photoelectric colorimeter. Journal of Laboratory and Clinical Medicine 27, 955960.Google Scholar
Graham, A. D., Christopherson, R. J. & Thompson, J. R. (1981). Endocrine and metabolic changes in sheep associated with acclimation to constant or intermittent cold exposure. Canadian Journal of Animal Science 61, 8190.CrossRefGoogle Scholar
Graham, A. D. & Phillips, G. D. (1981). Plasma glucose, lactate and free fatty acid responses to adrenaline in chronically warm- and cold-exposed sheep. Canadian Journal of Animal Science 61, 919924.CrossRefGoogle Scholar
Ho, R. G. & Meng, H. C. (1969). A simple and ultrasensitive method for determination of FFA by radiochemical assay. Analytical Biochemistry 31, 426436.CrossRefGoogle Scholar
Kraus-Friedman, N. (1984). Hormonal regulation of hepatic gluconeogenesis. Physiological Reviews 64, 170259.CrossRefGoogle Scholar
McKay, D. G., Young, B. A. & Milligan, L. P. (1974). Energy substrates for cold induced thermogenesis. In Energy Metabolism of Farm Animals (ed. Menke, K. H., Lantzech, H. J. and Reichl, J. R.), pp. 3942. Stuttgart: Universität Hohenheim.Google Scholar
McNatty, K. P. & Thurley, D. C. (1973). The episodic nature of changes in ovine plasma cortisol levels and their response to adrenaline during adaptation to a new environment. Journal of Endocrinology 59, 171180.CrossRefGoogle ScholarPubMed
Martens, H. & Rayssiguier, Y. (1980). Magnesium metabolism and hypomagnesaemia. In Digestive Physiology and Metabolism in Ruminants: Proceedings of the 5th International Symposium in Ruminant Physiology (ed. Ruckebusch, Y. and Thivend, P.), pp. 447466. Lancaster, England: MTP Press.CrossRefGoogle Scholar
Moberg, G. P., Anderson, C. O. & Underwood, T. R. (1980). Ontogeny of the adrenal and behavioural responses of lambs to emotional stress. Journal of Animal Science 51, 138142.CrossRefGoogle ScholarPubMed
Panaretto, B. A. (1974). Relationship of visceral blood flow to cortisol metabolism in cold stressed sheep. Journal of Endocrinology 60, 235245.CrossRefGoogle ScholarPubMed
Phillippo, M., Bruce, J. B. & Lawrence, C. B. (1970). The effect of adrenaline on calcitonin secretion in conscious sheep. Journal of Endocrinology 46, xiixiii.Google ScholarPubMed
Pugh, D. M. (1968). Some biochemical effects seen after the administration of synthetic adrenal cortex hormones to normal sheep. British Veterinary Journal 124, 259265.CrossRefGoogle ScholarPubMed
Purchas, R. W. (1973). The response of circulating cortisol levels in sheep to various stresses and to reserpine administration. Australian Journal of Biological Sciences 26, 477489.CrossRefGoogle ScholarPubMed
Rayssiguier, Y. (1977). Hypomagnesaemia resulting from adrenaline infusion in ewes; its relation to lipolysis. Hormone and Metabolic Research 9, 309314.CrossRefGoogle ScholarPubMed
Rayssiguier, Y. (1980). Metabolic disorders associated with hypomagnesaemia and hypocalcaemia in grass tetany in ruminants. In Metabolic Disorders in Farm Animals: Proceedings of the IVth International Conference on Production Disease in Farm Animals (ed. Giesecke, D., Dirkson, G. and Stangassinger, M.), pp. 196198. München, Germany. Institut für Physiologie, Physiologische Chimie und Ernahrungs-physiologie, Tierarztliche Fakultät der Universität München.Google Scholar
Reid, R. L. & Mills, S. C. (1962). Studies on the carbohydrate metabolism of sheep. XIV. The adrenal response to physiological stress. Australian Journal of Agricultural Research 13, 282295.CrossRefGoogle Scholar
Reilly, P. E. B. & Black, A. L. (1973). Early effects of cortisol on glucose and alanine metabolism in adrenalectomised sheep. American Journal of Physiology 225, 689695.CrossRefGoogle Scholar
Rowell, J. G. & Walters, D. E. (1976). Analysing data with repeated observations on each experimental unit. Journal of Agricultural Science, Cambridge 87, 423432.CrossRefGoogle Scholar
Scott, D. & Dobson, A. (1965). Aldosterone and the metabolism of magnesium and other minerals in the sheep. Quarterly Journal of Experimental Physiology 50, 4246.CrossRefGoogle Scholar
Silver, M. (1960). The output of adrenaline and nor-adrenaline from the adrenal medulla of the calf. Journal of Physiology 152, 1429.CrossRefGoogle ScholarPubMed
Terashima, Y., Tucker, R. E., Deetz, L. E., De-Gregorio, R. M., Muntifering, R. B. & Mitchell, G. E. Jr (1982). Plasma magnesium levels as influenced by cold exposure in fed or fasted sheep. Journal of Nutrition 112, 19141920.CrossRefGoogle ScholarPubMed
Willis, J. B. (1960). The determination of metals in blood serum by atomic absorption speotroscopy. II. Magnesium. Spectrochimica Acta 16, 273278.CrossRefGoogle Scholar