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Lipid production rates and the pathogenesis of fatty liver in fasted cows

Published online by Cambridge University Press:  27 March 2009

I. M. Reid ,
R. A. Collins ,
G. D. Baird ,
C. J. Roberts  and
H. W. Symonds
I. M. Reid
Affiliation:
Agricultural Research Council, Institute for Research on Animal Diseases, Compton, Newbury, Berkshire, RG16 ONN
R. A. Collins
Affiliation:
Agricultural Research Council, Institute for Research on Animal Diseases, Compton, Newbury, Berkshire, RG16 ONN
G. D. Baird
Affiliation:
Agricultural Research Council, Institute for Research on Animal Diseases, Compton, Newbury, Berkshire, RG16 ONN
C. J. Roberts
Affiliation:
Agricultural Research Council, Institute for Research on Animal Diseases, Compton, Newbury, Berkshire, RG16 ONN
H. W. Symonds
Affiliation:
Agricultural Research Council, Institute for Research on Animal Diseases, Compton, Newbury, Berkshire, RG16 ONN
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Summary

Lipid production across the liver was measured in catheterized dairy cows in vivo in the fed state and during 6 days of fasting. Production rates were calculated from the lipid concentrations in arterial, portal and hepatic-venous plasma and from the rates of plasma flow in the portal vein and the hepatic veins.

There was a consistent net hepatic output of triacylglycerol and a net hepatic uptake of free fatty acids in the fed state.

In the fasted state there was a significant change to a net hepatic uptake of triacylglycerol and an increased hepatic uptake of free fatty acids. Both factors are likely to result in an accumulation of triacylglycerol in the liver.

Type
Short Notes
Information
The Journal of Agricultural Science , Volume 93 , Issue 1 , August 1979 , pp. 253 - 256
Copyright
Copyright © Cambridge University Press 1979

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