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Special Issue: Psychosis from early intervention to treatment resistance

  • C. McDonald (a1) and D.R. Cotter (a2)

Abstract

Psychotic disorders are central to mental health service provision and a common theme of academic research programmes in Ireland, which explore the neurobiological and psychosocial risk factors underpinning the development and progression of these illnesses. While we await the discovery of novel pharmacological treatment targets for psychotic disorders, it is important to employ our existing management strategies to optimal effect. In this special issue on psychosis, a selection of clinical research studies and reviews from Irish researchers, and often of Irish populations, are brought together which span the trajectory of psychotic illness from early intervention to treatment resistance. The topics include the characteristics and course of first episode psychosis cohorts, real-world evaluation of early intervention services, management strategies for treatment resistant schizophrenia and neurobiological research into social stress. The current editorial provides an overview of these papers and highlights the initial steps of the Irish Psychosis Research Network towards developing an integrated clinical research network focusing on the treatment and research into psychotic disorders.

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Copyright

Corresponding author

*Address for correspondence: Professor C. McDonald, School of Medicine, Clinical Science Institute, National University of Ireland Galway, Galway, Ireland H91TK33. (Email: colm.mcdonald@nuigalway.ie)

References

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Donohoe, G, Dillon, R, Hargreaves, A, Mothersill, O, Castorina, M, Furey, E, Fagan, AJ, Meaney, JF, Fitzmaurice, B, Hallahan, B, McDonald, C, Wykes, T, Corvin, A, Robertson, IH (2018). Effectiveness of a low support, remotely accessible, cognitive remediation training programme for chronic psychosis: cognitive, functional and cortical outcomes from a single blind randomised controlled trial. Psychological Medicine 48, 751764.
Emsell, L, Leemans, A, Langan, C, Van Hecke, W, Barker, GJ, McCarthy, P, Jeurissen, B, Sijbers, J, Sunaert, S, Cannon, DM, McDonald, C (2013). Limbic and callosal white matter changes in euthymic bipolar I disorder: an advanced diffusion MRI tractography study. Biological Psychiatry 73, 194201.
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Madrid-Gambin, F, Föcking, M, Sabherwal, S, Heurich, M, English, J, O’Gorman, A, Suvitaival, T, Cannon, M, Lewis, G, Mattila, I, Scaife, C, Madden, S, Hyötyläinen, T, Orešič, M, Zammit, S, Cagney, G, Cotter, DR, Brennan, L (2019). Integrated lipidomics and proteomics point to early blood-based changes in childhood preceding later development of psychotic experiences: evidence from the Avon Longitudinal Study of Parents and Children. Biological Psychiatry 86, 2534.
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Mothersill, D, Dillon, R, Hargreaves, A, Castorina, M, Furey, E, Fagan, AJ, Meaney, JF, Fitzmaurice, B, Hallahan, B, McDonald, C, Wykes, T, Corvin, A, Robertson, IH, Donohoe, G (2018). Computerised working memory-based cognitive remediation therapy does not affect Reading the Mind in the Eyes test performance or neural activity during a Facial Emotion Recognition test in psychosis. European Journal of Neuroscience 48, 16911705. doi:10.1111/ejn.13976
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Keywords

Special Issue: Psychosis from early intervention to treatment resistance

  • C. McDonald (a1) and D.R. Cotter (a2)

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