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Parkinson's disease exacerbated by paroxetine

Published online by Cambridge University Press:  13 June 2014

John Moran
Affiliation:
University College Hospital Galway, Co Galway, Ireland

Abstract

Patients with Parkinson's disease are frequently treated by psychiatrists. We report on the exacerbation of parkinsonian symptoms in tw o patients prescribed paroxetine, an SSRI antidepressant. We discuss the possible mechanism for such an interaction.

Type
Case Reports
Copyright
Copyright © Cambridge University Press 1997

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References

1.Jansen Steur, ENH. Increase of Parkinson disability after fluoxetine medication. Neurology 1993; 43: 211–3.CrossRefGoogle Scholar
2.Meltzer, HY, Young, Met al.Extrapyramidal side-effects and increased serum prolactin following fluoxetine, a new antidepressant. J Neural Transm 1979; 45: 165–75.CrossRefGoogle ScholarPubMed
3.Tate, JL. Extrapyramidal symptoms in a patient taking haloperidol and fluoxetine. Am J Psychiatry 1989; 146(3): 399400.Google Scholar
4.Bouchard, RH, Pourcher, E, Vincent, P. Fluoxetine and extrapyramidal sideeffects. Am J Psychiatry 1989; 146(10): 1352–3.Google Scholar
5.TM, Brod. Fluoxetine and extrapyramidal side-effects. Am J Psychiatry 1989; 146(10): 1353.Google Scholar
6.Baldwin, D, Fineberg, N, Montgomery, D. Fluoxetine, fluvoxamine and extrapyramidal tract disorders. Int Clin Psychopharmacol 1991; 6: 51–8.CrossRefGoogle ScholarPubMed
7.Wils, V. Extrapyramidal symptoms in a patient treated with fluvoxamine. J Neurol Neurosurg Psychiatry 1992; 55: 330–1.CrossRefGoogle Scholar
8.Committee on Safety of Medicines. Dystonia and withdrawal symptoms with paroxetine. Curr Probl Pharmacol 1993; 19: 1.Google Scholar
9.Paroxetine and dystonia. Pharmaceut J 1993; 250: 303.Google Scholar
10.Nicholson, SD. Extrapyramidal side effects associated with paroxetine. West Engl Med J 1992; 107(3): 90–1.Google ScholarPubMed
11.Jimenez-Jimenez, FJ, Tejeiro, Jet al.Parkinsonism exacerbated by paroxetine. Neurology 1994; 44: 2406.CrossRefGoogle ScholarPubMed
12.Chase, TN. LKY, Ng, Watanabe, AM. Parkinson's disease. Modification by 5-hydroxytryptophan. Neurology 1972; 22: 479–84.CrossRefGoogle ScholarPubMed
13.Hall, CD, Weiss, EAet al.Rapid deterioration in patients with parkinsonism following tryptophan-pyridoxine administration. Neurology 1972; 22: 231–7.CrossRefGoogle ScholarPubMed
14.Baldessarini, RJ, Marsh, E. Fluoxetine and side-effects. Arch Gen Psychiatry 1990; 47: 191–2.CrossRefGoogle ScholarPubMed
15.Cummings, JL. Depression and Parkinson's disease: a review. Am J Psychiatry 1992; 4: 443–54.Google Scholar