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Homozygous mutation at cytochrome P4502D6 in an individual with schizophrenia: Implications for antipsychotic drugs, side effects and compliance

Published online by Cambridge University Press:  13 June 2014

Michael Gill ,
Ziarih Hawi  and
Marcus Webb
Marcus Webb
Affiliation:
Departments of Psychiatry and Genetics, Trinity Centre for Health Sciences, St James's Hospital, James's Street, Dublin 8, Ireland
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Abstract

We report the case of a patient with schizophrenia who has suffered severe side effects with many different antipsychotics. She is poorly compliant with treatment probably because of her experiences with medication. We determined her genotype at the CYP2D6 gene that codes for an enzyme principally involved in the metabolism of many antipsychotics. She was homozygous for the ‘B’ mutation, the most frequent of several known mutations. She therefore has no functioning CYP2D6 enzyme in common with 5%-10% of the population. This may explain why she is sensitive to quite moderate doses of antipsychotic medication, and more rational prescribing may lead to fewer side effects and increased compliance.

Keywords

Antipsychotic drugsGeneticsCYP2D6Cytochrome P450Side effects
Type
Case Reports
Information
Irish Journal of Psychological Medicine , Volume 14 , Issue 1 , March 1997 , pp. 38 - 39
Copyright
Copyright © Cambridge University Press 1997

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