Skip to main content Accessibility help
×
×
Home

Familial dementia with Pick's cells – a case report of probable familial Pick's disease

  • Fiona Gaughran (a1), Catherine Keohane (a2) and Mary Buckley (a3)

Abstract

The clinical and pathological features are described in a case of prolonged dementia in a 59 year old man with familial dementia and extrapyramidal disorder. Postmortem examination showed severe fronto-temporal and basal ganglia atrophy, with many “ballooned neurons” in the residual cortex most likely representing Pick's disease. The differential diagnosis is discussed and aspects of this rare condition are reviewed.

Copyright

References

Hide All
1.Heston, LL, Mastri, AR. Age at onset of Pick's and Alzheimer's dementia: implications for diagnosis and research. J Gerontol 1982; 37(4): 422–4.
2.Tomlinson, BE, Blessed, G, Roth, M. Observations on the brains of demented old people. J Neurol Sci 1970; 11: 205–42.
3.Pick, A. Uber die Beziehungen der senilen hirnatrophie zur Aphasie. Prager Med Wochenschr 1892; 17: 165–7.
4.Rewcastle, NB. In: Davis, RD, Robertson, DM, editors. “Textbook of Neuropathology”. 2nd ed. Baltimore MD: Williams & Wilkson, 1991: 918.
5.Sjogren, T, Sjogren, H, Lingren, GH. Morbus alzheimer and morbus pick: genetic, chemical and patho-anatomical study. Acta Psychiatr Scand 1952; 82 suppl: 166.
6.Heston, LL, White, JA, Mastri, AR. Pick's disease: clinical genetics and natural history. Arch Gen Psychiatry 1987; 44: 409–11.
7.Groen, JJ, Endtz, LJ. Hereditary Pick's disease. Second re-examination of a large family and discussion of other hereditary cases with particular reference to electroencephalography and computerised tomography. Brain 1982; 105: 443–59.
8.Cummings, JL, Duchen, LW. Kluver-Bucy syndrome in Pick's disease: clinical and pathologic correlations. Neurology NY 1981; 31(11): 1415–22.
9.Tomlinson, BE. In: Adams, JH, Duchen, LW, editors. Greenfield's Neuropathology. 5th ed. London: Edward Arnold, 1992: 1354–62.
10.Lowe, J, Errington, DR, Lennox, G, Pike, I, Splendlove, I, Landon, M, Mayer, RJ. Ballooned neurons in several neurodegenerative diseases and stroke contain alpha B crystallin. Neuropathol Appl Neurobiol 1992; 18(4): 341–50.
11.Moossy, J, Martinez, AJ, Hanin, I, Rao, G, Yonas, H, Boller, F. Thalamic and subcortical gliosis with dementia. Arch Neurol 1987; 44: 510–3.
12.Neary, D, Snowden, JS, Northern, B, Goulding, B. Dementia of frontal lobe type. J Neurol Neurosurg Psychiatry 1988; 51(3): 353–61.
13.Kim, RC, Collins, GH, Parisi, JE, Wright, AW, Chu, YB. Familial dementia of adult onset with pathological findings of a non specific nature. Brain 1981; 104: 6178.
14.Hsu, SM, Raine, L, Fanger, H. Use of avidin-biolin-peroxidasc complex (ABC) in immunoperoxidase techniques; a comparison between ABC and unlabelled antibody (PAP) procedures. J Histochem Cytochem 1981; 294: 577–80.
15.Knopman, DS, Christensen, KJ, Schut, LJ, Harbaugh, RE, Reeder, T, Ngo, T, Frey, W. The spectrum of imaging and neuropsychological findings in Pick's disease. Neurology 1989; 39(3): 362–8.
16.Kanazawa, I, Kwak, S, Sasaki, H, Muramoto, O, Mizutani, T, Hori, A, Nukina, N. Studies on the neurotransmitter markers of the basal ganglia in Pick's disease with special reference to dopamine reduction. J Neurol Sci. 1988; 83(1): 6374.
17.Winkleman, NW, Book, MH. Asymptomatic extrapyramidal involvement in Pick's disease: a clinicopathological study of two cases. J Neuropathol Exp Neurol 1949; 8: 3042.
18.Sam, M, Gutmann, L, Schochet, SS Jr, Doshi, H. Pick's disease: a case resembling amyotrophic lateral sclerosis. Neurology 1991; 41(11): 1831–3.
19.Yoshimuru, N. Topography of Pick body distribution in Pick's disease: a contribution to understanding the relationship between Pick's and Alzheimer's disease. Clin Neuropathol 1989; 8(1): 16.
20.Ulrich, J, Haugh, M, Anderton, BH, Probst, A, Lautenschlagcr, C, His, B. Alzheimer dementia and Pick's disease: neurofibrillary tangles and Pick bodies are associated with identical phosphorylated neurofilament epitopes. Acta Neuropathol (B) 1987; 73: 240–6.
21.Love, S, Burrola, P, Terry, RD, Wiley, CA. Immunoelectron microscopy of Alzheimer and Pick brain tissue labelled with the monoclonal antibody Alz 50. Neuropathol Appl Neurobiol 1989; 15(3): 223–31.
22.Brion, S, Plas, J, Jeanneau, A. Pick's disease: anatomo-clinical point of view. Rev Neurol (Paris) 1991; 147(11): 693704.
23.Sparks, DL, Woeltz, VM, Markesbery, WR. Alterations in brain monoamine oxidase activity in aging, Alzheimer's disease and Pick's disease. Arch Neurol 1991; 48(7): 718–21.
24.Van Mansvelt, J. Pick's disease: a syndrome of lobar cerebral atrophy [Thesis]. Enschede: Utrecht University, 1954.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Irish Journal of Psychological Medicine
  • ISSN: 0790-9667
  • EISSN: 2051-6967
  • URL: /core/journals/irish-journal-of-psychological-medicine
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed