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Factors that influence patients' attitudes to antipsychotic medication

Published online by Cambridge University Press:  13 June 2014

Farhan Haq ,
Caragh Behan ,
Nicola McGlade ,
Una Mulkerrin ,
Eadbhard O'Callaghan ,
Anthony Kinsella ,
Aiden Corvin ,
Gary Donohoe  and
Michael Gill
Farhan Haq*
Affiliation:
Dept of Psychiatry, University College Dublin, and Cluain Mhuire Family Centre, Newtownpark Avenue, Blackrock, Co Dublin, Ireland
Caragh Behan
Affiliation:
Dept of Psychiatry, University College Dublin, and Cluain Mhuire Family Centre, Newtownpark Avenue, Blackrock, Co Dublin, Ireland
Nicola McGlade
Affiliation:
Dept of Psychiatry, University College Dublin, and Cluain Mhuire Family Centre, Newtownpark Avenue, Blackrock, Co Dublin, Ireland
Una Mulkerrin
Affiliation:
Dept of Psychiatry, University College Dublin, and Cluain Mhuire Family Centre, Newtownpark Avenue, Blackrock, Co Dublin, Ireland
Eadbhard O'Callaghan
Affiliation:
Dept of Psychiatry, University College Dublin, and Cluain Mhuire Family Centre, Newtownpark Avenue, Blackrock, Co Dublin; and DETECT: Early Intervention in Psychosis Services, Dun Laoghaire, Co Dublin, Ireland
Anthony Kinsella
Affiliation:
DETECT, Early Intervention in Psychosis Services, Dun Laoghaire, Co Dublin, Ireland
Aiden Corvin
Affiliation:
Neuropsychiatric Genetics Research Group, Dept of Psychiatry, Trinity College, Dublin 2, Ireland
Gary Donohoe
Affiliation:
Neuropsychiatric Genetics Research Group, Dept of Psychiatry, Trinity College, Dublin 2, Ireland
Michael Gill
Affiliation:
Neuropsychiatric Genetics Research Group, Dept of Psychiatry, Trinity College, Dublin 2, Ireland
*
*Correspondence Email: farhanhaq08@gmail.com
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Abstract

Objective: The aim of this study was to investigate the attitudes to medication in relation to insight, purpose in life, symptoms and sociodemographic factors among a cohort of stable patients with a diagnosis of schizophrenia and schizoaffective disorder.

Method: We included 70 patients with a diagnosis of schizophrenia and schizoaffective disorder attending a Dublin suburban mental health service. All participants were 18 years or older and were excluded if they had a learning disability, acquired brain injury resulting in unconsciousness, and psychosis secondary to a general medical condition or illicit substance misuse. All participants were given self report questionnaires which included Drug Attitude Inventory (DAI-30), Birchwood Insight Scale, and Purpose in Life test. Symptoms were assessed using the Scale for Assessment of Positive and Negative symptoms. All data was analysed using the Statistical Package for the Social Sciences.

Results: We found that 86% (n = 60) of the participants had positive attitudes to medication, and 82% (n = 58) had good insight into their illness. Only 27% (n = 19) were found to have a definite purpose in life. There was a significant negative relationship between attitudes to medication and delusions (r = -0.25, n = 70, p < 0.05) and a significant positive relationship between insight and attitudes to medication (r = 0.0.28, n = 70, p < 0.05).

Conclusion: Many factors are involved in the multifaceted issue of attitudes to medication. Researchers must realise that these factors do not remain constant and may change with time and over the course of illness and treatment.

Keywords

Attitudes to medicationAdherenceInsightSchizophrenia
Type
Original Papers
Information
Irish Journal of Psychological Medicine , Volume 26 , Issue 1 , March 2009 , pp. 6 - 11
Copyright
Copyright © Cambridge University Press 2009

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References

1.DiMatteo, MRet al.Variations in patient's adherence to medical recommendations: a quantitative review of 50 years of research. Med Care 2004; 42: 200–9.CrossRefGoogle ScholarPubMed
2.Fenton, WS, Blyler, CR, Heinssen, RK. Determinants of medication compliance in schizophrenia: empirical and clinical findings: Schiz Bull 1997; 23: 637–651.CrossRefGoogle ScholarPubMed
3.Pool, VE, Elder, ST. A selected review of the literature and an empirical analysis of drug treatment compliance by schizophrenic patients. Int Rev Appl Psychol 1986; 35: 547–576.CrossRefGoogle Scholar
4.McEvoy, JP, Howe, AC, Hogarty, GE. Differences in the nature of relapse and subsequent inpatient course between medication, medication-compliant and noncompliant schizophrenic patients. J Nerv Ment Dis 1984; 172: 412–416.CrossRefGoogle ScholarPubMed
5.Leucht, S, Heres, Set al.Epidemiology, clinical consequences, and psychosocial treatment of nonadherence in schizophrenia J Clin Psychiatry 2006; 67(5): 3–8.Google Scholar
6.Ley, P.The problem of patients' non-compliance. In: Marcer, D, ed. Psychology and Health Series; vol 4. Communicating with Patients: Improving Communication, Satisfaction and Compliance. London, England: Chapman and Hall; 1992: 53–71.Google Scholar
7.Hofer, A, Rettenbacher, MA, Edlinger, M, Kemmler, G, Widschwendter, CG, Fleischhacker, WW. Subjective response and attitude toward antipsychotic drug therapy during the initial treatment period: a prospective follow-up study in patients with schizophrenia. Acta Psychiatr Scand 2007; 116(5): 354–61.CrossRefGoogle ScholarPubMed
8.Cabeza, IG, Amador, MS, Lopez, CA, Gonzalez de Chavez M. Subjective response to antipsychotics in schizophrenic patients: clinical implications and related factors. Schiz Res 2000; 21; 41 (2): 349–55.CrossRefGoogle ScholarPubMed
9.Lambert, M, Conus, P, Eide, Pet al.Impact present and past antipsychotic side effects on attitude toward typical antipsychotic treatment and adherence. Eur Psychiatry 2004; 19(7): 415–422.CrossRefGoogle ScholarPubMed
10.Kampman, O, Laippala, P, Vaananen, Jet al.Indicators of medication compliance in first-episode psychosis. Psychiatry Res 2004; 110(1): 39–48.CrossRefGoogle Scholar
11.O' Donnell, C, Donohoe, G, Sharkey, Let al.Compliance therapy: a randomised controlled trial in schizophrenia. BMJ 2003; 327: 834.CrossRefGoogle ScholarPubMed
12.Hogan, TP, Awad, AG, Eastwood, MR. A self-report scale predictive of drug compliance in schizophrenics: reliability and discriminative validity. Psychol Med 1983; 13: 177–183.CrossRefGoogle ScholarPubMed
13.Trauer, T, Sacks, T. The relationship between insight and medication adherence in severely mentally ill clients treated in the community. Acta Psychiat Scand 2000; 102: 211–216.CrossRefGoogle ScholarPubMed
14.Donohoe, G, Owens, N, O' Donnell, C, Burke, T, Moore, L, Tobin, A, O'Callaghan, E. Predictors of compliance with neuroleptic medication among inpatients with schizophrenia: a discriminant function analysis. Eur Psychiatry 2001; 16: 293–8.CrossRefGoogle ScholarPubMed
15.Kamali, M, Kelly, L, Gervin, M, Browne, S, Larkin, C, O'Callaghan, E. Psychopharmacology: Insight and Comorbid Substance Misuse and Medication Compliance Among Patients with Schizophrenia. Psychiatr Serv 2001; 52:161–166.CrossRefGoogle ScholarPubMed
16.Crumbaugh, , Maholick, LT. An experimental study in existentialism: the psychometric approach to Frankl's concept of noogenic neurosis. J Clin Psychol 1964; 20: 200–207.3.0.CO;2-U>CrossRefGoogle ScholarPubMed
17.Zika, S, Chamberlain, K. On the relation between meaning in life and psychological well being. Br J Psychol 1992; 83: 133–45.CrossRefGoogle ScholarPubMed
18.Thompson, N, Croker, J, Krause, J, Henry, E. Purpose in Life as a mediator of adjustment after spinal cord injury. Rehab Psychol 2003; 48: 100–108.CrossRefGoogle Scholar
19.Turner, N, Jackson, D, Renwick, Let al.What Influences Purpose in Life in First – Episode Psychosis? Br J Occupational Ther 2007: 70(8): 1–6.CrossRefGoogle Scholar
20.Birchwood, M, Smith, J, Drury, Vet al.A self-report insight scale for psychosis: reliability, validity and sensitivity to change. Acta Psychiatrica Scand 1994; 89: 62–67.CrossRefGoogle ScholarPubMed
21.Crumbaugh, Maholick LT. Manual of instructions for the purpose in life test. Murfreesboro, TN: Psychometric Affiliates, 1981.Google Scholar
22.Day, JC, Bentall, RP, Roberts, Cet al.Attitudes toward Antipsychotic Medication; the Impact of Clinical Variables and Relationships with Health Professionals. Arch Gen Psychiatry 2005; 62: 717–724.CrossRefGoogle ScholarPubMed
23.Marder, SR, Mebane, A, Ckien, CP, Winslade, WJ, Swann, E, Van Putten, T. A comparison of patients who refuse and consent to neuroleptic treatment. Am J Psychiatry 1983; 140: 470–472.Google ScholarPubMed
24.Barkto, G, Herczeg, I, Zador, G. Clinical symptomatology and drug compliance in schizophrenic patients. Acta Psychiatr Scand 1988; 77: 74–76.Google Scholar
25.Garavan, J, Browne, S, Gervin, M, Lane, A, Larkin, C, O'Callaghan, E. Compliance with Neuroleptic Medication in Outpatients with Schizophrenia; Relationship to Subjective Response to Neuroleptics; Attitudes to Medication and Insight. Compr Psychiatry 1998; 39:215–219CrossRefGoogle ScholarPubMed
26.Kroenke, K. Polypharmacy: Causes, consequences, and cure. Am J Med 1985; 79: 149–152.CrossRefGoogle ScholarPubMed
27.Murray, MD. Polypharmacy: Management of therapeutic regimens. In: Mezey, MD, Bottrell, MM, Berkman, BJ (Eds). The Encyclopedia of Elder Care: The Comprehensive Resource on Geriatric and Social Care. New York: Springer Publishing Company; 2000.Google Scholar
28.Kamali, M, Kelly, BD, Clarke, Met al.A prospective evaluation of adherence to medication in first episode schizophrenia: Eur Psychiatry 2006; 21 (1): 29–33.Google Scholar
29.DiMatteo, MR. Social support and patient adherence to medical treatment: a metaanalysis. Health Psychol 2004; 23: 207–18.CrossRefGoogle ScholarPubMed