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Down's syndrome, dementia and macrocytosis

  • Vee Prasher (a1), Jay Viswanathan (a2) and Roger Holder (a3)

Abstract

Objective: No definitive peripheral biological marker has yet been found to correlate with Alzheimer's disease (AD). This study investigated the role of macrocytosis as a marker which could significantly improve our understanding of AD in the Down's syndrome (DS) population.

Methods: This study investigated the possible association between raised mean corpuscular volume (MCV) and AD in 150 adults with DS over a five year study period.

Results: A raised MCV is common in the DS population. A statistically significant association between a further elevated MCV and clinically diagnosed AD in adults with DS was found.

Conclusions: The findings suggest that further research into the association between macrocytosis and DS could improve our understanding of the underlying biological mechanisms of AD. The measurement of MCV should be undertaken in all DS individuals with a diagnosis of possible or definite dementia. A significant raised MCV (above 97fl for males and 99fl for females) may further improve the clinical diagnosis. A single MCV measurement, however, cannot be recommended as a diagnostic test for AD in adults with DS.

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References

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1.Burns, A. Clinical diagnosis of Alzheimer's disease. Dementia 1991, 2; 186194.
2.Goodall, HB, McHarg, JF, Anderson, JM, Robertson, J. Acanthocytosis in disparate clinical states-myelodysplasia and Alzheimer's disease. Leukemia Research 1991; 15 (Supplement): 19.
3.Goodall, HBet al.Irregular distortion of the erythrocytes (Acanthocytes, Spur Cells) in senile dementia. Disease Markers 1994; 12: 2341.
4.Eastham, RD, Jancar, J. Macrocytosis in Down's syndrome and during long-term anticonvulsant therapy. J Clin Pathology 1970; 23: 296298.
5.Eastham, RD, Jancar, J. Macrocytosis and Down's syndrome. Br J Psychiatry 1983; 143: 203204.
6.Hewitt, KE, Carter, G, Jancer, J. Ageing in Down's syndrome. Br J Psychiatry 1985; 147: 5862.
7.Terman, LM, Merrill, MA. Measuring Intelligence. Boston: Houghton Mifflin, 1937
8.Lansdall-Welfare, RW, Hewitt, KE. Macrocytosis and cognitive decline in Down's syndrome. Br J Psychiatry 1986; 148: 482–3.
9.Akin, K. Macrocytosis and leukopenia in Down's syndrome. J Am Med Association 1988; 259: 842.
10.Wachtel, TJ, Peuschel, SM. Macrocytosis in Down syndrome. Am J Mental Retardation 1991; 95: 417–20.
11.Prasher, VP. Increase in mean cell volume – a possible peripheral marker for Alzheimer's disease? J Int Geriatric Psychiatry 1997; 12: 130–1.
12.Prasher, VP. Down syndrome, dementia and macrocytosis. Br J Developmental Disabilities 1994; 90: 131134.
13.World Health Organisation. The ICD-10 Classification of Mental and Behavioural Disorders. Diagnostic Criteria for Research. Geneva: WHO, 1993
14.Prasher, VP. Screening of physical morbidity in adults with Down syndrome. Down's Syndrome Research and Practice 1994; 2: 5966.
15.World Health Organisation. The ICD-10 Classification of Mental and Behavioural Disorders. Clinical Descriptions and Diagnostic Guidelines. Geneva: WHO, 1992
16.World Health Organisation. ICD-10 Symptom Checklist for Mental Disorders. Version 1.1. Geneva: WHO, 1994
17.Roth, Met al.CAMDEX. A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. Br J Psychiatry 1986; 149: 698709.
18.Aylward, EHet al.Diagnosis of dementia in individuals with intellectual disability. J Intellectual Disability Res 1997; 41, 152164.
19.Tycko, DH. Flow-cytometric light scattering measurement of red blood cell volume and haemoglobin concentration. Applied Optics 1985; 24: 13551365.
20.Dickinson, MJ, Singh, I. Down's syndrome, dementia, and superoxide dismutase. Br J Psychiatry 1993; 162: 811–7.
21.Bosman, GJet al.Erythrocyte membrane changes of individuals with Down's syndrome in various stages of Alzheimer-type dementia. Neurobiology of Aging 1993, 14; 223–8.
22.Lee, GRet al.Clinical Haematology. Philadelphia: Lea and Febiger, 1993
23.Nakamura, E, Tanaka, S. Biological ages of adult men and women with Down's syndrome and its changes with aging. Mechanisms of Ageing and Development 1998; 105: 89103.
24.Okamoto, Net al.Premature aging syndrome with osteosarcoma, cataracts, diabetes mellitus, osteoporosis, erythroid macrocytosis, severe growth and developmental deficiency. Am J Medical Genetics 1997; 69: 169170.
25.Hanin, Iet al.Elevated red blood cell/plasma choline ratio in dementia of the Alzheimer type: clinical and polysomnography correlates. Psychiatry Research 1984; 13: 167173.
26.Greenwald, BSet al.Alzheimer's disease, dexamethasone suppression, dementia severity, and affective symptoms. Am J Psychiatry 1986; 143: 442446.
27.Sinet, PM. Metabolism of oxygen derivatives in Down's Syndrome. Annals of the New York Academy of Sciences 1982; 396: 8394.
28.Marcus, DLet al.Increased peroxidation and reduced antioxidant enzyme activity in Alzheimer's disease. Exp Neurology 1998; 150: 40–4.
29.Subbarao, KV, Richardson, JS, Ang, L. Autopsy samples of Alzheimer's cortex show increase peroxidation in vitro. J Neurochemistry 1990; 55: 342345.
30.Blass, JPet al.Red blood cell abnormalities in Alzheimer disease. J Am Geriatric Society 1985; 33: 401–5.

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