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Volumetric reduction in various cortical regions of elderly patients with early-onset and late-onset mania

Published online by Cambridge University Press:  18 June 2010

Shou-Hung Huang ,
Shang-Ying Tsai ,
Jung-Lung Hsu  and
Yi-Lin Huang
Shou-Hung Huang
Affiliation:
Department of Psychiatry and Psychiatric Research Center, Taipei Medical University Hospital, Taipei, Taiwan
Shang-Ying Tsai*
Affiliation:
Department of Psychiatry and Psychiatric Research Center, Taipei Medical University Hospital, Taipei, Taiwan Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan Department of Psychiatry, Po-Jen General Hospital, Taipei, Taiwan
Jung-Lung Hsu
Affiliation:
Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
Yi-Lin Huang
Affiliation:
Department of Psychiatry and Psychiatric Research Center, Taipei Medical University Hospital, Taipei, Taiwan
*
Correspondence should be addressed to: Professor Shang-Ying Tsai, Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan. #252 Wu-Hsing Street, Taipei, 110, Taiwan. Phone: +886-2-22344850; Fax: +886-2-27368829. Email: tmcpsyts@tmu.edu.tw.
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Abstract

Background: Few studies have examined alterations of the brain in elderly bipolar patients. As late-onset mania is associated with increased cerebrovascular morbidity and neurological damage compared with typical/early-onset mania, we investigated differences in the volume of various cortical regions between elderly patients with early-onset versus late-onset mania.

Methods: We recruited 44 bipolar patients aged over 60 years, who underwent volumetric magnetic resonance imaging at 1.5 T. The analytic method is based on the hidden Markov random field model with an expectation-maximization algorithm. We determined the volume of each cortical region as a percentage of the total intracranial volume. The cutoff age for defining early versus late onset was 45 years.

Results: The study participants consisted of 25 patients with early-onset mania and 19 patients with late-onset mania; their mean ages were 65.7 years and 62.8 years, respectively. The demographic variables of the two groups were comparable. The volumes of the left caudate nucleus (p = 0.022) and left middle frontal gyrus (p = 0.013) were significantly greater and that of the right posterior cingulate gyrus (p = 0.019) was significantly smaller in the late-onset group. More patients with late-onset mania had comorbid cerebrovascular disease (p = 0.072).

Conclusions: The right posterior cingulate gyrus is smaller and the left caudate nucleus and left middle frontal gyrus are larger in patients with late-onset mania compared with those with early-onset mania. Volumetric change in brain regions may vary in elderly bipolar patients with early and late-onset mania.

Keywords

volumetric MRI studybipolar I disorderelderlylate-onset
Type
Research Article
Information
International Psychogeriatrics , Volume 23 , Issue 1 , February 2011 , pp. 149 - 154
Copyright
Copyright © International Psychogeriatric Association 2010

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