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Preserved brain metabolic activity at the age of 96 years

  • Ivayla Apostolova (a1), Catharina Lange (a2), Lothar Spies (a3), Kerstin Ritter (a4), Anja Mäurer (a5), Joachim Seybold (a5) (a6), Jochen B. Fiebach (a7), Elisabeth Steinhagen-Thiessen (a8) and Ralph Buchert (a2)...

Extract

Loss of brain tissue becomes notable to cerebral magnetic resonance imaging (MRI) at age 30 years, and progresses more rapidly from mid 60s. The incidence of dementia increases exponentially with age, and is all too frequent in the oldest old (≥ 90 years of age), the fastest growing age group in many countries. However, brain pathology and cognitive decline are not inevitable, even at extremely old age (den Dunnen et al., 2008).

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References

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Caselli, R. J., Chen, K., Lee, W., Alexander, G. E. and Reiman, E. M. (2008). Correlating cerebral hypometabolism with future memory decline in subsequent converters to amnestic pre-mild cognitive impairment. Archives of Neurology, 65, 12311236.
den Dunnen, W. F. et al. (2008). No disease in the brain of a 115-year-old woman. Neurobiology of Aging, 29, 11271132.
Inouye, S. K., Viscoli, C. M., Horwitz, R. I., Hurst, L. D. and Tinetti, M. E. (1993). A predictive model for delirium in hospitalized elderly medical patients based on admission characteristics. Annals of Internal Medicine, 119, 474481.
Knopman, D. S. et al. (2014). 18F-fluorodeoxyglucose positron emission tomography, aging, and apolipoprotein E genotype in cognitively normal persons. Neurobiology of Aging, 35, 20962106.
Lange, C., Suppa, P., Frings, L., Brenner, W., Spies, L. and Buchert, R. (2015). Optimization of statistical single subject analysis of brain FDG PET for the prognosis of mild cognitive impairment-to-Alzheimer's disease conversion. Journal of Alzheimers Disease, 49, 945959.
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Preserved brain metabolic activity at the age of 96 years

  • Ivayla Apostolova (a1), Catharina Lange (a2), Lothar Spies (a3), Kerstin Ritter (a4), Anja Mäurer (a5), Joachim Seybold (a5) (a6), Jochen B. Fiebach (a7), Elisabeth Steinhagen-Thiessen (a8) and Ralph Buchert (a2)...

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