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Multiple system atrophy due to prolonged valproic acid treatment

Published online by Cambridge University Press:  23 April 2007

BARBARA BORRONI ,
ANNA ROSATI ,
CHIARA COSTANZI ,
ROBERTO ZULLI ,
DICRAM MARDIGHIAN ,
ROBERTO GASPAROTTI  and
ALESSANDRO PADOVANI
BARBARA BORRONI
Affiliation:
Neurology Unit, University of Brescia, Italy Email: bborroni@inwind.it
ANNA ROSATI
Affiliation:
Neurology Unit, University of Brescia, Italy Email: bborroni@inwind.it
CHIARA COSTANZI
Affiliation:
Neurology Unit, University of Brescia, Italy Email: bborroni@inwind.it
ROBERTO ZULLI
Affiliation:
Neurology Unit, University of Brescia, Italy Email: bborroni@inwind.it
DICRAM MARDIGHIAN
Affiliation:
Neurology Unit, University of Brescia, Italy Email: bborroni@inwind.it
ROBERTO GASPAROTTI
Affiliation:
Neurology Unit, University of Brescia, Italy Email: bborroni@inwind.it
ALESSANDRO PADOVANI
Affiliation:
Neurology Unit, University of Brescia, Italy Email: bborroni@inwind.it
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Abstract

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Studies reported in the literature indicate a wide range of movement disorders associated with anti-epileptic treatment (Easterford et al., 2004). Valproic acid is a well-known cause of reversible neurotoxicity characterized by symptoms resembling idiopathic Parkinson's disease (PD) and cognitive impairment (Armon et al., 1996; Onofrj et al., 1998).

Type
Letter
Information
International Psychogeriatrics , Volume 19 , Issue 4 , August 2007 , pp. 780 - 782
Copyright
International Psychogeriatric Association 2007