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May neuropsychiatric symptoms be a potential intervention target to delay functional impairment in Alzheimer’s disease?

Published online by Cambridge University Press:  03 July 2020

Antonios M. Politis*
Affiliation:
Division of Geriatric Psychiatry, 1st Department of Psychiatry, Eginition Hospital, Athens Medical School, National and Kapodistrian University of Athens, Athens, Greece Department of Psychiatry, Johns Hopkins Medical School, Baltimore, MD, USA
Panagiotis Alexopoulos
Affiliation:
Department of Psychiatry, University Hospital of Rion, School of Medicine, University of Patras, Patras, Greece Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
Theofanis Vorvolakos
Affiliation:
Department of Psychiatry, University General Hospital of Alexandroupolis, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece

Abstract

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Type
Commentary
Copyright
© International Psychogeriatric Association 2020

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References

Alexopoulos, G.S. (2019). Mechanisms and treatment of late-life depression. Translation Psychiatry, 9, 188.CrossRefGoogle ScholarPubMed
Amanzio, M.etal. (2018). Neuropsychological correlates of instrumental activities of daily living in neurocognitive disorders: a possible role for executive dysfunction and mood changes. International Psychogeriatrics, 30, 18711881.CrossRefGoogle ScholarPubMed
Benoit, M.etal. (1999). Behavioral and psychological symptoms in Alzheimer’s disease. Relation between apathy and regional cerebral perfusion. Dementia and Geriatric Cognitive Disorders, 10, 511517.CrossRefGoogle ScholarPubMed
Brodaty, H. (2012). Nonpharmacological Management of Apathy in Dementia: A Systematic Review. American Journal Geriatric Psychiatry, 7, 549564CrossRefGoogle Scholar
Burton, R.L.etal. (2018). Cognitive and neuropsychiatric correlates of functional impairment across the continuum of no cognitive impairment to dementia. Archives Clinical Neuropsychology, 33, 795807.CrossRefGoogle Scholar
Delgado, C.etal. (2019). Neuropsychiatric symptoms in Alzheimer’s Disease are the main determinants of Functional Impairment in advanced every day activities. Journal of Alzheimer’s Disease, 67, 381392.CrossRefGoogle Scholar
Farias, S.etal. (2009). Longitudinal changes in memory and executive functioning are associated with longitudinal changes in instrumental activities of daily living in older adults. The Clinical Neuropsychologist, 23, 446461.CrossRefGoogle Scholar
Holthoff, V.A.etal. (2005). Regional cerebral metabolism in early Alzheimer’s disease with clinically significant apathy or depression. Biological Psychiatry, 57, 412421.CrossRefGoogle ScholarPubMed
Ismail, Z.etal. (2017). Prevalence of depression in patients with mild cognitive impairment: A systematic review and meta-analysis. JAMA Psychiatry, 74, 5867.CrossRefGoogle ScholarPubMed
Ismail, Z.etal. (2018). Affective and emotional dysregulation as pre-dementia risk markers: Exploring the mild behavioral impairment symptoms of depression, anxiety, irritability and euphoria. International Psychogeriatrics, 30, 185196.CrossRefGoogle ScholarPubMed
Lanctôt, K.L.etal. (2017). Apathy associated with neurocognitive disorders: recent progress and future directions. Alzheimer’s Dementia, 13, 84100.CrossRefGoogle ScholarPubMed
Lyketsos, C.C. (2009). Forgotten frontal lobe syndrome or “Executive Dysfunction Syndrome.” Psychosomatics, 45, 247255.CrossRefGoogle Scholar
Perneczky, R.etal. (2006). Complex activities of daily living in mild cognitive impairment: conceptual and diagnostic issues. Age Ageing, 35, 240245.CrossRefGoogle ScholarPubMed
Reed, C.etal. (2016). Identifying factors of activities of daily living important for cost and caregiver outcomes in Alzheimer’s disease. International Psychogeriatrics, 28, 247259.CrossRefGoogle ScholarPubMed
Robb, C.etal. (2017). Biomarkers and functional decline in prodromal Alzheimer’s disease. Journal of Alzheimer’s Disease, 58, 6978.CrossRefGoogle ScholarPubMed
Rog, L.A.etal. (2014). The independent contributions of cognitive impairment and neuropsychiatric symptoms to everyday function in older adults. Clinical Neurpsychology, 28, 215236.CrossRefGoogle ScholarPubMed
Saari, T.etal. (2019). Neuropsychiatric symptoms and activities of daily living in Alzheimer’s disease: ALSOVA 5-year follow-up study. International Psychogeriatrics, 32, 741751.CrossRefGoogle ScholarPubMed
Steinberg, M.etal. (2008). Point and 5-year period prevalence of neuropsychiatric symptoms in dementia : the cache County Study. International Journal Geriatric Psychiatry, 2, 170177.CrossRefGoogle Scholar
Theleritis, C.etal. (2014). A review of neuroimaging findings of apathy in Alzheimer’s disease. International Psychogeriatrics, 26, 195207.CrossRefGoogle ScholarPubMed
U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Biologics Evaluation. (2018). Early Alzheimer’s Disease: Developing Drugs For Treatment, Guidelines for Industry. https://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM596728.pdf.Google Scholar
Yonas, E.G.etal. (2013). Neuropsychiatric symptoms in Alzheimer’s disease: Past progress and anticipation of the future. Alzheimer’s Dementia, 9, 602608.Google Scholar