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IL-6 release by LPS-stimulated peripheral blood mononuclear cells as a potential biomarker in Alzheimer's disease

  • Adam Kaplin (a1), Katherine A. L. Carroll (a2), Jenn Cheng (a3), Rameeza Allie (a4), Constantine G. Lyketsos (a1), Peter Calabresi (a4) and Paul B. Rosenberg (a1)...

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There is increasing evidence for the role of activated microglia in the neurotoxic pathways of Alzheimer's disease (AD). Amyloid-β1-42 is a potent activator of microglia (Benveniste et al., 2001), causing them to release pro-inflammatory cytokines including IL-6, IL-1β, TNF-α among others. A peripheral blood marker reflecting CNS inflammatory processes would be useful for treatment development, but the search for such an in vivo marker has been elusive. Peripheral blood and CSF levels of pro-inflammatory cytokines do not consistently differ in AD and controls (reviewed in Rosenberg, 2005). Both microglia and peripheral blood mononuclear cells (PBMCs) release pro-inflammatory cytokines when exposed to immunologic stimuli including lipopolysaccharide (LPS) and phytohemagglutinin (PHA). There are recent data suggesting that PBMCs from AD patients release more cytokines in this paradigm than normal controls (Reale et al., 2004).

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References

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Benveniste, E. N., Nguyen, V. T. and O'Keefe, G. M. (2001). Immunological aspects of microglia: relevance to Alzheimer's disease. Neurochemistry International, 39, 381391.
Miller, A. H. and Raison, C. L. (2006). Cytokines, p38 MAP kinase and the pathophysiology of depression. Neuropsychopharmacology, 31, 20892090.
Reale, M. et al. (2004). Treatment with an acetylcholinesterase inhibitor in Alzheimer patients modulates the expression and production of the pro-inflammatory and anti-inflammatory cytokines. Journal of Neuroimmunology, 148, 162171.
Rosenberg, P. B. (2005). Clinical aspects of inflammation in alzheimer's disease. International Review of Psychiatry, 17, 503514.
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IL-6 release by LPS-stimulated peripheral blood mononuclear cells as a potential biomarker in Alzheimer's disease

  • Adam Kaplin (a1), Katherine A. L. Carroll (a2), Jenn Cheng (a3), Rameeza Allie (a4), Constantine G. Lyketsos (a1), Peter Calabresi (a4) and Paul B. Rosenberg (a1)...

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