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The association between prostate cancer and mood disorders: a nationwide population-based study in Taiwan

  • Pan-Ming Chen (a1), San-Chi Chen (a2), Chia-Jen Liu (a2) (a3), Man-Hsin Hung (a2), Chia-Fen Tsai (a4) (a5), Yu-Wen Hu (a6), Mu-Hong Chen (a4), Cheng-Che Shen (a7), Tung-Ping Su (a4) (a5), Chiu-Mei Yeh (a8), Ti Lu (a9), Tzeng-Ji Chen (a5) (a8) and Li-Yu Hu (a9)...

Abstract

Background:

This study identified possible risk factors for newly diagnosed mood disorders, including depressive and bipolar disorders, in prostate cancer patients.

Methods:

From 2000 to 2006, two cohorts were evaluated on the occurrence of mood disorder diagnosis and treatment. For the first cohort, data of patients diagnosed with prostate cancer was obtained from the Taiwan National Health Insurance (NHI) Research Database. As the second cohort, a cancer-free comparison group was matched for age, comorbidities, geographic region, and socioeconomic status.

Results:

Final analyses involved 12,872 men with prostate cancer and 12,872 matched patients. Increased incidence of both depressive (IRR 1.52, 95% CI 1.30–1.79, P <0.001) and bipolar disorder (IRR 1.84, 95% CI 1.25–2.74, P = 0.001) was observed among patients diagnosed with prostate cancer. Multivariate matched regression models show that cerebrovascular disease (CVD) and radiotherapy treatment could be independent risk factors for developing subsequent depressive and bipolar disorders.

Conclusion:

We observed that the risk of developing newly diagnosed depressive and bipolar disorders is higher among Taiwanese prostate cancer patients. Clinicians should be aware of the possibility of increased depressive and bipolar disorders among prostate cancer patients in Taiwan. A prospective study is necessary to confirm these findings.

Copyright

Corresponding author

Correspondence should be addressed to: Li-Yu Hu, M.D. Department of Psychiatry, Kaohsiung Veterans General Veterans Hospital, Taiwan 386, Ta-Chung 1st Rd., Tzuo-Yin Dist., Kaohsiung City 81362, Taiwan. Phone: +886-7-3422121; Fax: +886-7-3468346. Email: chrishuly@gmail.com.

References

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Abbott, N. J., Ronnback, L. and Hansson, E. (2006). Astrocyte-endothelial interactions at the blood-brain barrier. Nature Reviews Neuroscience, 7, 4153.
American Cancer Society (2013). Cancer Facts & Figures 2013. Avalibale at: http://www.cancer.org/acs/groups/content/@epidemiologysurveilance/documents/document/acspc-036845.pdf; last accessed 20 April 2014.
Bailey, R. K., Geyen, D.J., Scott-Gurnell, K., Hipolito, M.M., Bailey, T.A. and Beal, J. M. (2005). Understanding and treating depression among cancer patients. International Journal of Gynecological Cancer, 15, 203208.
Bill-Axelson, A. et al. (2010). Suicide risk in men with prostate-specific antigen-detected early prostate cancer: a nationwide population-based cohort study from PCBaSe Sweden. European Urology, 57, 390395.
Bill-Axelson, A. et al. (2011). Psychiatric treatment in men with prostate cancer–results from a Nation-wide, population-based cohort study from PCBaSe Sweden. European Journal of Cancer, 47, 21952201.
Brintzenhofe-Szoc, K. M., Levin, T. T., Li, Y., Kissane, D. W. and Zabora, J. R. (2009). Mixed anxiety/depression symptoms in a large cancer cohort: prevalence by cancer type. Psychosomatics, 50, 383391.
Cherrier, M. M., Aubin, S. and Higano, C. S. (2009). Cognitive and mood changes in men undergoing intermittent combined androgen blockade for non-metastatic prostate cancer. Psychooncology, 18, 237247.
Chochinov, H. M. (2001). Depression in cancer patients. The Lancet Oncology, 2, 499505.
De Marzo, A. M. et al. (2007). Inflammation in prostate carcinogenesis. Nature Reviews Cancer, 7, 256269.
Fall, K. et al. (2009). Immediate risk for cardiovascular events and suicide following a prostate cancer diagnosis: prospective cohort study. PLoS Medicine, 6, e1000197.
Fang, F. et al. (2010). Immediate risk of suicide and cardiovascular death after a prostate cancer diagnosis: cohort study in the United States. Journal of the National Cancer Institute, 102, 307314.
Hu, L. Y. et al. (2013). Hyperthyroidism and risk for bipolar disorders: a nationwide population-based study. PLoS One, 8, e73057.
Huang, K. L., Su, T. P., Chen, T. J., Chou, Y. H. and Bai, Y. M. (2009). Comorbidity of cardiovascular diseases with mood and anxiety disorder: a population based 4-year study. Psychiatry and Clinical Neurosciences, 63, 401409.
Khan, A. Y., Ludvigson, L. R., Stewart, M. and Gorman, J. M. (2007). Menopause manifesting as bipolar symptoms. Journal of Psychiatric Practice, 13, 339342.
Khan, N. F., Perera, R., Harper, S. and Rose, P. W. (2010a). Adaptation and validation of the Charlson index for read/OXMIS coded databases. BMC Family Practice, 11, 1.
Khan, N. F., Ward, A. M., Watson, E. and Rose, P. W. (2010b). Consulting and prescribing behaviour for anxiety and depression in long-term survivors of cancer in the UK. European Journal of Cancer, 46, 33393344.
Lajeunesse, C., Parent, R. and Villeneuve, A. (1986). Manic-like episode following flutamide treatment. The American Journal of Psychiatry, 143, 14981499.
Lin, H. P., Deng, C. Y. and Chou, P. (2009). Diagnosis and treatment delay among pulmonary tuberculosis patients identified using the Taiwan reporting enquiry system, 2002–2006. BMC Public Health, 9, 55.
Lintz, K. et al. (2003). Prostate cancer patients’ support and psychological care needs: survey from a non-surgical oncology clinic. Psycho-oncology, 12, 769783.
Maggio, M. et al. (2006). Circulating inflammatory cytokine expression in men with prostate cancer undergoing androgen deprivation therapy. Journal of Andrology, 27, 725728.
McCarron, S. L. et al. (2002). Influence of cytokine gene polymorphisms on the development of prostate cancer. Cancer Research, 62, 33693372.
Munkholm, K., Vinberg, M. and Vedel Kessing, L. (2013). Cytokines in bipolar disorder: a systematic review and meta-analysis. Journal of Affective Disorders, 144, 1627.
Pfitzenmaier, J., Vessella, R., Higano, C.S., Noteboom, J.L., Wallace, D. Jr. and Corey, E. (2003). Elevation of cytokine levels in cachectic patients with prostate carcinoma. Cancer, 97, 12111216.
Pu, Y., Chiang, H., Lin, C., Huang, C., Huang, K. and Chen, J. (2004). Changing trends of prostate cancer in Asia. The Aging Male, 7, 120132.
Seidman, S. N. et al. (2002). Low testosterone levels in elderly men with dysthymic disorder. American Journal of Psychiatry, 159, 456459.
Sharpley, C. F., Bitsika, V. and Christie, D. R. (2012). Do patient-reported androgen-deprivation therapy side effects predict anxiety and depression among prostate cancer patients undergoing radiotherapy? Implications for psychosocial therapy interventions. Journal of Psychosocial Oncology, 30, 185197.
Sher, L. et al. (2012). Testosterone levels in suicide attempters with bipolar disorder. Journal of Psychiatric Research, 46, 12671271.
Steineck, G. et al. (2002). Quality of life after radical prostatectomy or watchful waiting. New England Journal of Medicine, 347, 790796.
Townsend, L., Walkup, J. T., Crystal, S. and Olfson, M. (2012). A systematic review of validated methods for identifying depression using administrative data. Pharmacoepidemiology and Drug Safety, 21, 163173.
Van Onselen, C. et al. (2010). Relationship between mood disturbance and sleep quality in oncology outpatients at the initiation of radiation therapy. European Journal of Oncology Nursing, 14, 373379.
van Tol-Geerdink, J. J., Leer, J. W., van Lin, E. N., Schimmel, E. C. and Stalmeier, P. F. (2011). Depression related to (neo)adjuvant hormonal therapy for prostate cancer. Radiotherapy Oncology, 98, 203206.
Wiechno, P. J., Sadowska, M., Kalinowski, T., Michalski, W. and Demkow, T. (2013). Does pharmacological castration as adjuvant therapy for prostate cancer after radiotherapy affect anxiety and depression levels, cognitive functions and quality of life? Psychooncology, 22, 346351.
Wu, C. S., Wang, S. C., Cheng, Y. C. and Gau, S. S. (2011). Association of cerebrovascular events with antidepressant use: a case-crossover study. American Journal of Psychiatry, 168, 511521.

Keywords

The association between prostate cancer and mood disorders: a nationwide population-based study in Taiwan

  • Pan-Ming Chen (a1), San-Chi Chen (a2), Chia-Jen Liu (a2) (a3), Man-Hsin Hung (a2), Chia-Fen Tsai (a4) (a5), Yu-Wen Hu (a6), Mu-Hong Chen (a4), Cheng-Che Shen (a7), Tung-Ping Su (a4) (a5), Chiu-Mei Yeh (a8), Ti Lu (a9), Tzeng-Ji Chen (a5) (a8) and Li-Yu Hu (a9)...

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