Skip to main content Accessibility help
×
Home
Hostname: page-component-558cb97cc8-fpk9s Total loading time: 0.382 Render date: 2022-10-07T20:42:30.696Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "useRatesEcommerce": false, "displayNetworkTab": true, "displayNetworkMapGraph": false, "useSa": true } hasContentIssue true

RETRACTED - Risk factors for mild behavioral impairment in non-demented geriatrics: a population-based survey in Taiwan

Published online by Cambridge University Press:  10 May 2021

Yee-Lam E. Chan
Affiliation:
Department of Psychiatry, Cheng Hsin General Hospital, Taipei, Taiwan
Chih-Ming Cheng
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Division of Psychiatry, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
Mao-Hsuan Huang
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Yuanshan and Suao Branch, Taipei, Taiwan Division of Psychiatry, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
Huey-Jane Lee
Affiliation:
Taiwan Alzheimer Disease Association, Taipei, Taiwan
Li-Yu Tang
Affiliation:
Taiwan Alzheimer Disease Association, Taipei, Taiwan
Chia-Fen Tsai*
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Division of Psychiatry, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan Taiwan Alzheimer Disease Association, Taipei, Taiwan
*
Correspondence should be addressed to: Chia-Fen Tsai, Department of Psychiatry, Taipei Veterans General Hospital, No. 201, Shih-Pai Road, Sec. 2, 11217, Taipei, Taiwan. Phone: 886 -2- 28757027; Fax: 886 -2- 28757592. E-mail: cftsai@vghtpe.gov.tw

Abstract

Objectives:

To investigate potential risk factors for mild behavioral impairment (MBI) among non-demented geriatrics.

Design:

Population-based, cross-sectional survey.

Setting:

Taiwan Alzheimer Disease Association (TADA) Database.

Participants:

Participants were selected by multistage random sampling of all Taiwan counties. They received in-person interviews between December 2011 and March 2013.

Measurements:

Demographic data, lifestyle and habits, medical comorbidities, cognitive status measured by the Taiwanese Mini-Mental Status Examination (TMSE) and presence of MCI of the participants were collected. Subjects were distributed to the MBI and non-MBI groups. These factors had been evaluated for their effects on MBI in the univariate and multivariable logistic regression models.

Results:

In total, 6,196 non-demented participants aged 65 years or older, including 409 MBI and 5,787 non-MBI participants, were recruited. After adjustment for age, sex, education, body mass index, lifestyle and habits, medical comorbidities, and MCI, good sleep was associated with lower risk of MBI (OR 0.09, 95% CI 0.07 – 0.12). Low body weight (OR 2.01, 95% CI 1.21–3.33), low-to-medium education (OR 1.40, 95%CI 1.06–1.85; OR 2.32, 95% CI 1.67–3.21), medical comorbidities of hypertension (OR 1.56, 95% CI 1.25–1.95), hyperlipidemia (OR 1.29, 95% CI 1.00–1.67), cancer (OR 2.05, 95% CI 1.37–3.06) were significantly associated with increased MBI risk. MCI neither increased nor decreased risk of MBI (OR 1.00, 95% CI 0.76–1.32).

Conclusions:

Good sleep was associated with lower MBI risk. Underweight, lower education, medical comorbidities of cancer, hypertension, hyperlipidemia were predictive of MBI.

Type
Original Research Article
Copyright
© International Psychogeriatric Association 2021

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

This article was retracted in November 2021. See doi:10.1017/S1041610221002635.

References

Albert, M. S. et al. (2011). The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimer’s & Dementia, 7, 270279.10.1016/j.jalz.2011.03.008CrossRefGoogle Scholar
Alhurani, R. E. et al. (2016). Decline in Weight and Incident Mild Cognitive Impairment: Mayo Clinic Study of Aging. JAMA Neurology, 73, 439446.10.1001/jamaneurol.2015.4756CrossRefGoogle ScholarPubMed
Apostolova, L. G. et al. (2014). Risk factors for behavioral abnormalities in mild cognitive impairment and mild Alzheimer’s disease. Dementia and Geriatric Cognitive Disorders, 37, 315326.10.1159/000351009CrossRefGoogle ScholarPubMed
Bjelland, I., Krokstad, S., Mykletun, A., Dahl, A. A., Tell, G. S. and Tambs, K. (2008). Does a higher educational level protect against anxiety and depression? The HUNT study. Social Science & Medicine, 66, 13341345.10.1016/j.socscimed.2007.12.019CrossRefGoogle ScholarPubMed
Brodaty, H. et al. (2012). Neuropsychiatric symptoms in older people with and without cognitive impairment. Journal of Alzheimer’s Disease, 31, 411420.10.3233/JAD-2012-120169CrossRefGoogle ScholarPubMed
Carvalho, D. Z. et al. (2018). Association of Excessive Daytime Sleepiness With Longitudinal beta-Amyloid Accumulation in Elderly Persons Without Dementia. JAMA Neurology, 75, 672680.10.1001/jamaneurol.2018.0049CrossRefGoogle ScholarPubMed
Chen, T. B. et al. (2017). Comorbidity and dementia: a nationwide survey in Taiwan. PLoS One, 12, e0175475.10.1371/journal.pone.0175475CrossRefGoogle ScholarPubMed
Cheng, C. M. et al. (2018). Association of Polypharmacy With Mild Cognitive Impairment and Cognitive Ability: A Nationwide Survey in Taiwan. Journal of Clinical Psychiatry, 79.Google ScholarPubMed
Chiaie, R. D. et al. (2011). Symptomatic subsyndromal depression in hospitalized hypertensive patients. Journal of Affective Disorders, 135, 168176.10.1016/j.jad.2011.07.008CrossRefGoogle ScholarPubMed
Creese, B. et al. (2019). Mild Behavioral Impairment as a Marker of Cognitive Decline in Cognitively Normal Older Adults. American Journal of Geriatric Psychiatry, 27, 823834.10.1016/j.jagp.2019.01.215CrossRefGoogle ScholarPubMed
Creese, B. et al. (2020). Profile of mild behavioral impairment and factor structure of the Mild Behavioral Impairment Checklist in cognitively normal older adults. International Psychogeriatrics, 32, 705717.10.1017/S1041610219001200CrossRefGoogle ScholarPubMed
da Silva, R. A. (2015). Sleep disturbances and mild cognitive impairment: a review. Sleep Sci, 8, 3641.10.1016/j.slsci.2015.02.001CrossRefGoogle ScholarPubMed
de Almondes, K. M., Costa, M. V., Malloy-Diniz, L. F. and Diniz, B. S. (2016). Insomnia and risk of dementia in older adults: systematic review and meta-analysis. J Psychiatr Res, 77, 109115.10.1016/j.jpsychires.2016.02.021CrossRefGoogle ScholarPubMed
Diem, S. J. et al. (2016). Measures of Sleep-Wake Patterns and Risk of Mild Cognitive Impairment or Dementia in Older Women. American Journal of Geriatric Psychiatry, 24, 248258.10.1016/j.jagp.2015.12.002CrossRefGoogle ScholarPubMed
Ismail, Z. et al. (2016). Neuropsychiatric symptoms as early manifestations of emergent dementia: provisional diagnostic criteria for mild behavioral impairment. Alzheimer’s & Dementia, 12, 195202.10.1016/j.jalz.2015.05.017CrossRefGoogle ScholarPubMed
Ismail, Z. et al. (2017). The Mild Behavioral Impairment Checklist (MBI-C): A Rating Scale for Neuropsychiatric Symptoms in Pre-Dementia Populations. Journal of Alzheimer’s Disease, 56, 929938.10.3233/JAD-160979CrossRefGoogle ScholarPubMed
Jee, H. J., Shin, W., Jung, H. J., Kim, B., Lee, B. K. and Jung, Y. S. (2020). Impact of Sleep Disorder as a Risk Factor for Dementia in Men and Women. Biomolecules & Therapeutics (Seoul), 28, 5873.10.4062/biomolther.2019.192CrossRefGoogle ScholarPubMed
Jekel, K. et al. (2015). Mild cognitive impairment and deficits in instrumental activities of daily living: a systematic review. Alzheimer’s Research & Therapy, 7, 17.10.1186/s13195-015-0099-0CrossRefGoogle ScholarPubMed
Knopman, D. S. and Petersen, R. C. (2014). Mild cognitive impairment and mild dementia: a clinical perspective. Mayo Clinic Proceedings, 89, 14521459.10.1016/j.mayocp.2014.06.019CrossRefGoogle ScholarPubMed
Lucey, B. P. et al. (2018). Effect of sleep on overnight cerebrospinal fluid amyloid beta kinetics. Annals of Neurology, 83, 197204.10.1002/ana.25117CrossRefGoogle ScholarPubMed
Lussier, F. Z. et al. (2020). Mild behavioral impairment is associated with beta-amyloid but not tau or neurodegeneration in cognitively intact elderly individuals. Alzheimer’s & Dementia, 16, 192199.10.1002/alz.12007CrossRefGoogle ScholarPubMed
Lyketsos, C. G. et al. (2011). Neuropsychiatric symptoms in Alzheimer’s disease. Alzheimer’s & Dementia, 7, 532539.10.1016/j.jalz.2011.05.2410CrossRefGoogle ScholarPubMed
Lyketsos, C. G., Lopez, O., Jones, B., Fitzpatrick, A. L., Breitner, J. and DeKosky, S. (2002). Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study. JAMA, 288, 14751483.10.1001/jama.288.12.1475CrossRefGoogle ScholarPubMed
Mahendran, R., Lim, H. A., Tan, J. Y., Kua, E. H. and Griva, K. (2016). The prevalence and predictors of subsyndromal anxiety and depression in adult Asian cancer patients across the first year of diagnosis. Asia-Pacific Journal of Clinical Oncology, 12, 476489.10.1111/ajco.12562CrossRefGoogle ScholarPubMed
Malhotra, R. K. (2018). Neurodegenerative Disorders and Sleep. Sleep Medicine Clinics, 13, 6370.10.1016/j.jsmc.2017.09.006CrossRefGoogle ScholarPubMed
Manjavong, M., Limpawattana, P., Mairiang, P. and Anutrakulchai, S. (2016). Prevalence of insomnia and related impact. International Journal of Psychiatry in Medicine, 51, 544553.10.1177/0091217417696731CrossRefGoogle ScholarPubMed
Matsuoka, T., Ismail, Z. and Narumoto, J. (2019). Prevalence of Mild Behavioral Impairment and Risk of Dementia in a Psychiatric Outpatient Clinic. Journal of Alzheimer’s Disease, 70, 505513.10.3233/JAD-190278CrossRefGoogle Scholar
McKeith, I. G. et al. (2017). Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB Consortium. Neurology, 89, 88100.10.1212/WNL.0000000000004058CrossRefGoogle ScholarPubMed
McKhann, G. M. et al. (2011). The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimer’s & Dementia, 7, 263269.10.1016/j.jalz.2011.03.005CrossRefGoogle Scholar
Minger, S. L. et al. (2000). Cholinergic deficits contribute to behavioral disturbance in patients with dementia. Neurology, 55, 14601467.10.1212/WNL.55.10.1460CrossRefGoogle ScholarPubMed
Morris, J. C. (1993). The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology, 43, 24122414.10.1212/WNL.43.11.2412-aCrossRefGoogle ScholarPubMed
Mortby, M. E., Ismail, Z. and Anstey, K. J. (2018). Prevalence estimates of mild behavioral impairment in a population-based sample of pre-dementia states and cognitively healthy older adults. International Psychogeriatrics, 30, 221232.10.1017/S1041610217001909CrossRefGoogle Scholar
O’Brien, J. T. et al. (2017). Clinical practice with anti-dementia drugs: a revised (third) consensus statement from the British Association for Psychopharmacology. Journal of Psychopharmacology, 31, 147168.10.1177/0269881116680924CrossRefGoogle ScholarPubMed
Pan, A. et al. (2012). Bidirectional association between depression and metabolic syndrome: a systematic review and meta-analysis of epidemiological studies. Diabetes Care, 35, 11711180.10.2337/dc11-2055CrossRefGoogle ScholarPubMed
Pase, M. P. et al. (2017). Sleep architecture and the risk of incident dementia in the community. Neurology, 89, 12441250.10.1212/WNL.0000000000004373CrossRefGoogle Scholar
Rosenberg, P. B., Mielke, M. M., Appleby, B. S., Oh, E. S., Geda, Y. E. and Lyketsos, C. G. (2013). The association of neuropsychiatric symptoms in MCI with incident dementia and Alzheimer disease. American Journal of Geriatric Psychiatry, 21, 685695.10.1016/j.jagp.2013.01.006CrossRefGoogle ScholarPubMed
Shi, L. et al. (2018). Sleep disturbances increase the risk of dementia: a systematic review and meta-analysis. Sleep Medicine Reviews, 40, 416.10.1016/j.smrv.2017.06.010CrossRefGoogle ScholarPubMed
Shokri-Kojori, E. et al. (2018). beta-Amyloid accumulation in the human brain after one night of sleep deprivation. Proceedings of the National Academy of Sciences of the United States of America, 115, 44834488.10.1073/pnas.1721694115CrossRefGoogle ScholarPubMed
Shyu, Y. I. and Yip, P. K. (2001). Factor structure and explanatory variables of the Mini-Mental State Examination (MMSE) for elderly persons in Taiwan. Journal of the Formosan Medical Association, 100, 676683.Google ScholarPubMed
Sobow, T., Fendler, W. and Magierski, R. (2014). Body mass index and mild cognitive impairment-to-dementia progression in 24 months: a prospective study. European Journal of Clinical Nutrition, 68, 12161219.10.1038/ejcn.2014.167CrossRefGoogle ScholarPubMed
Stella, F., Radanovic, M., Balthazar, M. L., Canineu, P. R., de Souza, L. C. and Forlenza, O. V. (2014). Neuropsychiatric symptoms in the prodromal stages of dementia. Current Opinion in Psychiatry, 27, 230235.10.1097/YCO.0000000000000050CrossRefGoogle ScholarPubMed
Sun, Y. et al. (2014). A nationwide survey of mild cognitive impairment and dementia, including very mild dementia, in Taiwan. PLoS One, 9, e100303.10.1371/journal.pone.0100303CrossRefGoogle Scholar
Taragano, F. E. et al. (2009). Mild behavioral impairment and risk of dementia: a prospective cohort study of 358 patients. Journal of Clinical Psychiatry, 70, 584592.10.4088/JCP.08m04181CrossRefGoogle ScholarPubMed
Taragano, F. E. et al. (2018). Risk of Conversion to Dementia in a Mild Behavioral Impairment Group Compared to a Psychiatric Group and to a Mild Cognitive Impairment Group. Journal of Alzheimer’s Disease, 62, 227238.10.3233/JAD-170632CrossRefGoogle Scholar
Tolppanen, A. M. et al. (2014). Midlife and late-life body mass index and late-life dementia: results from a prospective population-based cohort. Journal of Alzheimer’s Disease, 38, 201209.10.3233/JAD-130698CrossRefGoogle ScholarPubMed
Westwood, A. J. et al. (2017). Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia. Neurology, 88, 11721179.10.1212/WNL.0000000000003732CrossRefGoogle ScholarPubMed
Yi, J. C. and Syrjala, K. L. (2017). Anxiety and Depression in Cancer Survivors. Medical Clinics of North America, 101, 10991113.10.1016/j.mcna.2017.06.005CrossRefGoogle ScholarPubMed
1
Cited by

Linked content

Please note a has been issued for this article.

Save article to Kindle

To save this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

RETRACTED - Risk factors for mild behavioral impairment in non-demented geriatrics: a population-based survey in Taiwan
Available formats
×

Save article to Dropbox

To save this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you used this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about saving content to Dropbox.

RETRACTED - Risk factors for mild behavioral impairment in non-demented geriatrics: a population-based survey in Taiwan
Available formats
×

Save article to Google Drive

To save this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you used this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about saving content to Google Drive.

RETRACTED - Risk factors for mild behavioral impairment in non-demented geriatrics: a population-based survey in Taiwan
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *