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The feasibility of harmonizing health technology assessments across jurisdictions: A case study of drug eluting stents

  • Paul Trueman (a1), Manjusha Hurry (a1), Matthew Bending (a1) and John Hutton (a1)


Objectives: There is considerable interest in the potential for harmonizing health technology assessments (HTA) across jurisdictions. This study aims to consider four HTAs of drug eluting stents to determine the degree to which the methods adopted, evidence considered, and resulting recommendations diverge.

Methods: Four HTAs of drug eluting stents were selected for inclusion and evaluated using a framework developed to systematically capture information on the process adopted, the evidence considered and the recommendations of each HTA.

Results and Conclusions: The findings suggest that, although there is a common core data set considered by most of the agencies, differences in the approach to HTA, heterogeneity of studies, and the limited relevance of research findings to local practice meant that the core data set had only limited influence on the resulting recommendations. Of the HTA agencies considered in the analysis, many sought to generate additional primary research from local settings to help inform the development of recommendations that were relevant to local practice. This raises questions about the extent to which HTA methods can be harmonized across jurisdictions.



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1. Banta, D. The development of health technology assessment. Health Policy. 2003;63:121132.
2. Bowen, J, Hopkins, R, He, Y, et al. Systematic review and cost effectiveness analysis of drug eluting stents compared to bare metal stents for percutaneous coronary interventions in Ontario. Final Report. PATH Research Institute; May 2007.
3. Busse, R, Orvain, J, Velasco, M, et al. Best practice in undertaking and reporting Health Technology Assessments. Int J Technol Assess Health Care. 2002;18:361422.
4. Centre for Reviews & Dissemination. Systematic reviews: CRD's guidance for undertaking reviews in healthcare. University of York, United Kingdom: Centre for Reviews & Dissemination; January 2009.
5. Core HTA. Drug eluting stents. European Network for Health Technology Assessment, work package 4, draft report, July 2007. (accessed on April 22, 2009).
6. Cranovsky, R, Matillion, Y, Banta, HD. EUR-ASSESS project subgroup on coverage. Int. J Technol Assess Health Care. 1997;13:287332.
7. Culyer, AJ, Lomas, J. Deliberative processes and evidence-informed decision-making in health care: do they work and how might we know? Evid Policy. 2006;2:357371.
8. Hill, R, Boland, A, Dickson, R, et al. Drug eluting stents: A systematic review and economic evaluation. Health Technol Assess. 2007;11: iii, xi-221.
9. HTA Core Model for Medical and Surgical Interventions. European Network for Health Technology Assessment, work package 4, draft report, July 2007. (accessed on April 22, 2009).
10. EUnetHTA: European Network for Health Technology Assessment. (accessed April 21, 2009).
11. Hutton, J, Trueman, P, Facey, K. Harmonisation of evidence requirements for health technology assessment in reimbursement decision making. Int J Technol Assess Health Care. 2008;24:511517.
12. Jonsson, E, Banta, HD, Henshall, C, Sampietro-Colom, L. Summary report of the ECHTA/ECAHI project. European Collaboration for Health Technology Assessment/Assessment of Health Interventions. Int J Technol Assess Health Care. 2002;18:218237.
13. Kvas, E. Drug eluting stents in comparison to uncoated stents in the treatment of cardiopathy. Rapid Assessment. LBI-HTA 01, 2006.
14. Ong, AT, McFadden, EP, Regar, E, et al. Late angiographic stent thrombosis (LAST) events with drug eluting stents. J Am Coll Cardiol. 2005;45:20882092.
15. Vinck, I, Neyt, M, Thiry, N, et al. Drug eluting stents in Belgium. Health technology assessment. Belgian Healthcare Knowledge Centre (KCE); 2007.
16. Weinstein, MC, O'Brien, B, Hornberger, J, et al. Principles of good practice for decision analytic modelling in health care evaluation: Report of the ISPOR task force on good research practices – modelling studies. Value Health. 2003;6:917.



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