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Variability of surgical prophylaxis in penicillin-allergic children

  • David F. Butler (a1), Brian R. Lee (a1), Sarah Suppes (a2), Tracy Sandritter (a2), Jason G. Newland (a3), Lory Harte (a2) and Jennifer L. Goldman (a1)...


We retrospectively evaluated the effect of penicillin adverse drug reaction (ADR) labeling on surgical antibiotic prophylaxis. Cefazolin was administered in 86% of penicillin ADR-negative (−) and 28% penicillin ADR-positive (+) cases. Broad-spectrum antibiotic use was more common in ADR(+) cases and was more commonly associated with perioperative adverse drug events.


Corresponding author

Authors for correspondence: David F. Butler, MD, Division of Pediatric Critical Care Medicine, Department of Pediatrics, Seattle Children’s Hospital, University of Washington School of Medicine, FA.2.112, 4800 Sand Point Way NE, Seattle WA 98105. E-mail: Also, Jennifer Goldman MD, MS Divisions of Pediatric Infectious Diseases & Clinical Pharmacology, Department of Pediatrics, Children’s Mercy Hospital, 2401 Gillham Rd, Kansas City, MO 64108. E-mail:


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Present affiliation: Division of Pediatric Critical Care, University of Washington, Seattle Children’s Hospital, Seattle, Washington.

Cite this article: Butler DF et al. (2018). Variability of surgical prophylaxis in penicillin-allergic children. Infection Control & Hospital Epidemiology 2018, 39, 1480–1483. doi: 10.1017/ice.2018.244



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Variability of surgical prophylaxis in penicillin-allergic children

  • David F. Butler (a1), Brian R. Lee (a1), Sarah Suppes (a2), Tracy Sandritter (a2), Jason G. Newland (a3), Lory Harte (a2) and Jennifer L. Goldman (a1)...


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