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Using Clinical Scenarios to Understand Preventability of Clostridium difficile Infections by Inpatient Antibiotic Stewardship Programs

  • Jessica Seidelman (a1), Kristen V. Dicks (a2), Michael J. Durkin (a3), Arthur W. Baker (a2), Rebekah W. Moehring (a2) (a4) (a5), Deverick J. Anderson (a2) (a4), Daniel J. Sexton (a2) (a4), Luke F. Chen (a2) (a4) and Sarah S. Lewis (a2) (a4)...


Corresponding author

Address correspondence to Jessica Seidelman, Medical Education Office Department of Medicine DUMC Box 3182 Durham, NC 27710 (


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1. Gerding, DN, Muto, CA, Owens, RC Jr. Measures to control and prevent Clostridium difficile infection. Clin Infect Dis 2008;46:S43S49.
2. Cohen, SH, Gerding, DN, Johnson, S, et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infect Control Hosp Epidemiol 2010;31:431455.
3. Vindigni, SM, Surawicz, CM. C. difficile infection: changing epidemiology and management paradigms. Clin Transl Gastroenterol 2015;6:e99.
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5. McDonald, LC, Coignard, B, Dubberke, E, Song, X, Horan, T, Kutty, PK. Recommendations for surveillance of Clostridium difficile–associated disease. Infect Control Hosp Epidemiol 2007;28:140145.
6. Durkin, MJ, Baker, AW, Dicks, KV, et al. A comparison between national healthcare safety network laboratory-identified event reporting versus traditional surveillance for Clostridium difficile infection. Infect Control Hosp Epidemiol 2015;36:125131.
7. Ranji, SR, Steinman, MA, Shojania, KG, Gonzales, R. Interventions to reduce unnecessary antibiotic prescribing: a systematic review and quantitative analysis. Med Care 2008;46:847862.
8. Ranji, SR, Steinman, MA, Shojania, KG, et al. Closing the quality gap: a critical analysis of quality improvement strategies (Vol. 4: Antibiotic prescribing behavior). Technical Reviews, No. 9.4. Rockville, MD: Agency for Healthcare Research and Quality (US); 2006.
9. Tartof, SY, Rieg, GK, Wei, R, Tseng, HF, Jacobsen, SJ, Yu, KC. A comprehensive assessment across the healthcare continuum: risk of hospital-associated Clostridium difficile infection due to outpatient and inpatient antibiotic exposure. Infect Control Hosp Epidemiol 2015:18.
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