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Trends in Chlorhexidine Use in US Neonatal Intensive Care Units: Results From a Follow-Up National Survey

  • Julia Johnson (a1), Rebecca Bracken (a2), Pranita D. Tamma (a3), Susan W. Aucott (a1), Cynthia Bearer (a2) and Aaron M. Milstone (a3)...


Corresponding author

Address correspondence to Julia Johnson, MD, Division of Neonatology, Department of Pediatrics, Charlotte R. Bloomberg Children’s Center, 1800 Orleans St, Ste 8513, Baltimore, MD 21287 (


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1. Milstone, AM, Passaretti, CL, Perl, TM. Chlorhexidine: expanding the armamentarium for infection control and prevention. Clin Infect Dis 2008;46:274281.
2. Marschal, J, Mermel, LA, Fakih, M, et al. Strategies to prevent central line–associated bloodstream infections in acute care hospitals: 2014 update. Infect Control Hosp Epidemiol 2014;35:753771.
3. Quach, C, Milstone, AM, Perpête, C, Bonenfant, M, Moore, DL, Perreault, T. Chlorhexidine bathing in a tertiary care neonatal intensive care unit: impact on central line–associated bloodstream infections. Infect Control Hosp Epidemiol 2014;35:158163.
4. Tamma, PD, Aucott, SW, Milstone, AM. Chlorhexidine use in the neonatal intensive care unit: results from a national survey. Infect Control Hosp Epidemiol 2010;31:846849.
5. Hocevar, DN, Lessa, FC, Gallagher, L, Conover, C, Gorwitz, R, Iwamoto, M. Infection prevention practices in neonatal intensive care units reporting to the National Healthcare Safety Network. Infect Control Hosp Epidemiol 2014;35:11261132.
6. Klieger, SB, Potter-Bynoe, G, Quach, C, Sandora, TJ, Coffin, SE. Beyond the bundle: a survey of central line–associated bloodstream infection prevention practices used in US and Canadian pediatric hospitals. Infect Control Hosp Epidemiol 2013;34:12081210.
7. Chapman, AK, Aucott, SW, Gilmore, MM, Advani, S, Clarke, W, Milstone, AM. Absorption and tolerability of aqueous chlorhexidine gluconate used for skin antisepsis prior to catheter insertion in preterm neonates. J Perinatol 2013;33:768771.
8. Milstone, AM, Bamford, P, Aucott, SW, Tang, N, White, KR, Bearer, CF. Chlorhexidine inhibits L1 cell adhesion molecule-mediated neurite outgrowth in vitro. Pediatr Res 2014;75:813.
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