Hostname: page-component-76fb5796d-wq484 Total loading time: 0 Render date: 2024-04-26T22:45:50.333Z Has data issue: false hasContentIssue false

The Threat of Biological Terrorism: A Public Health and Infection Control Reality

Published online by Cambridge University Press:  02 January 2015

Robert J. Leggiadro*
Affiliation:
Department of Pediatrics, Sisters of Charity Medical Center, Staten Island, New York, andthe New York University School of Medicine, New York City, New York
*
Department of Pediatrics, Sisters of Charity Medical Center, 355 Bard Ave, Staten Island, NY 10310

Abstract

Bioterrorism is an emerging public health and infection control threat. Potential biological agents include smallpox, anthrax, plague, tularemia, botulinum toxin, brucellosis, Q fever, viral encephalitis, hemorrhagic fever, and staphylococcal enterotoxin B. An understanding of the epidemiology, clinical manifestations, and management of the more likely candidate agents is critical to limiting morbidity and mortality from a biological event. Effective response requires an increased index of suspicion for unusual diseases or syndromes, with prompt reporting to health authorities to facilitate recognition of an outbreak and subsequent intervention. Hospital epidemiology programs will play a crucial role in this effort.

Type
Review
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2000

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Henderson, DA. Bioterrorism as a public health threat. Emerg Infect Dis 1998;4:488492.Google Scholar
2.McDade, JE, Franz, D. Bioterrorism as a public health threat. Emerg Infect Dis 1998;4:493494.CrossRefGoogle ScholarPubMed
3.Franz, DR, Jahrling, PB, Friedlander, AM, McClain, DJ, Hoover, DL, Bryne, WRet al. Clinical recognition and management of patients exposed to biological warfare agents. JAMA 1997;278:399411.Google Scholar
4.Christopher, GW, Cieslak, TJ, Pavlin, JAEitzen, EM Jr. Biological warfare. A historical perspective. JAMA 1997;278:412417.CrossRefGoogle ScholarPubMed
5.Henderson, DAInglesby, TV, Bartlett, JG, Ascher, MS, Eitzen, E, Jahrling, PB, et al. Smallpox as a biological weapon: medical and public health management. Working Group on Civilian Biodefense. JAMA 1999;281:21272137.CrossRefGoogle Scholar
6.LaForce, FM. Anthrax. Clin Infect Dis 1994;19:10091014.CrossRefGoogle ScholarPubMed
7.Pile, JC, Malone, JD, Eitzen, EM, Friedlander, AM. Anthrax as a potential biological warfare agent. Arch Intern Med 1998;158:429434.Google Scholar
8.Inglesby, TV, Henderson, DA, Bartlett, JG, Ascher, MS, Eitzen, E, Friedlander, AM, et al. Anthrax as a biological weapon: medical and public health management. Working Group on Civilian Biodefense. JAMA 1999;281:17351745.Google Scholar
9.Meselson, M, Guillemin, J, Hugh-Jones, M, Langmuir, A, Popova, I, Shelokov, A, et al. The Sverdlovsk anthrax outbreak of 1979. Science 1994;266:12021208.CrossRefGoogle ScholarPubMed
10.Centers for Disease Control and Prevention. Bioterrorism alleging use of anthrax and interim guidelines for management—United States, 1998. MMWR 1999;48:6974.Google Scholar
11.Centers for Disease Control and Prevention. Prevention of plague: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR 1996;45(RR-14):115.Google Scholar
12.Centers for Disease Control and Prevention. Fatal human plague— Arizona and Colorado, 1996. MMWR 1997;46:617620.Google Scholar
13.Mann, JM, Shandler, L, Cushing, AH. Pediatric plague. Pediatrics 1982;69:762767.CrossRefGoogle ScholarPubMed
14.Evans, ME, Gregory, DW, Schaffner, W, McGee, ZA. Tularemia: a 30-year experience with 88 cases. Medicine (Baltimore) 1985;64:251269.CrossRefGoogle ScholarPubMed
15.Jacobs, RF, Narain, JP. Tularemia in children. Pediatr Infect Dis 1983;2:487491.CrossRefGoogle ScholarPubMed
16.Leggiadro, RJ. Tetracycline for Rocky Mountain spotted fever. Pediatrics 1991;87:124125.Google Scholar