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Spiking of intravenous bags does not cause time-dependent microbial contamination: a preliminary report

  • John G. Brock-Utne (a1), Sara C. Smith (a1), Niaz Banaei (a2), Shao-Ching Chang (a2), Diane Alejandro-Harper (a1) and Richard A. Jaffe (a1)...


Corresponding author

Address for correspondence: John G Brock-Utne MD, PhD, Stanford University Medical Center, 300 Pasteur Drive, Room H3580, Stanford, CA 94305-5640. E-mail:


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1. Pharmaceutical compounding—sterile preparations. In: US Pharmacopeia, chapter 797. Rockville, MD: The United States Pharmacopeia Convention; 2011.
2. Dolan, SA, Felizerda, G, Barnes, S, et al. APIC position paper: safe injection, infusion, and medication vital practices in health care. Am J Infect Control 2010;38:167172.
3. Stedman, JL, Yarmush, JM, Joshi, MC, Kamath, S, Schianodicola, J. How long is too long? The prespiked intravenous debate. Anesth Analg 2017;124:15641568.
4. Haas, R, Beitz, E, Reed, A, et al. No bacterial growth found in spiked intravenous fluids over an 8-hour period. Am J Infect Control 2017;45:448450.
5. Guynn, JB, Poretz, DM, Duma, RJ. Growth of various bacteria in a variety of intravenous fluids. Amer J Hosp Pharm 1973;30:321325.


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