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A Regional Outbreak of Clostridium difficile PCR-Ribotype 027 Infections in Southeastern France from a Single Long-Term Care Facility

  • Nadim Cassir (a1) (a2), Jean-Christophe Delarozière (a3), Gregory Dubourg (a1), Marion Delord (a2), Jean-Christophe Lagier (a1) (a2), Phillipe Brouqui (a1) (a2), Florence Fenollar (a1), Didier Raoult (a1) and Pierre Edouard Fournier (a1)...



To describe and analyze a large outbreak of Clostridium difficile 027 (CD-027) infections.


Confirmed CD-027 cases were defined as CD infection plus real-time polymerase chain reaction assay (PCR) positive for CD-027. Clinical and microbiological data on patients with CD-027 infection were collected from January 2013 to December 2015 in the Provence-Alpes-Côte-d’Azur region (southeastern France).


In total, 19 healthcare facilities reported 144 CD-027 infections (112 confirmed and 32 probable CD-027 infections) during a 22-month period outbreak. Although the incidence rate per 10,000 bed days was lower in long-term care facilities (LTCFs) than in acute care facilities (0.05 vs 0.14; P<.001), cases occurred mainly in LTCFs, one of which was the probable source of this outbreak. After centralization of CD testing, the rate of confirmed CD-027 cases from LTCFs or residential-care homes increased significantly (69% vs 92%; P<.001). Regarding confirmed CD-027 patients, the sex ratio and the median age were 0.53 and 84.2 years, respectively. The 30-day crude mortality rate was 31%. Most patients (96%) had received antibiotics within 3 months prior to the CD colitis diagnosis. During the study period, the rate of patients with CD-027 (compared with all patients tested in the point-of-care laboratories) decreased significantly (P=.03).


A large CD-027 outbreak occurred in southeastern France as a consequence of an initial cluster of cases in a single LTCF. Successful interventions included rapid isolation and testing of residents with potentially infectious diarrhea and cohorting of case patients in a specialized infectious diseases ward to optimize management.

Infect Control Hosp Epidemiol 2016;1–5


Corresponding author

Address correspondence to Pierre E. Fournier, MD, PhD, Unité de Recherche sur les Maladies Infectieuses Tropicales et Emergentes, UMR CNRS-7278, IRD189, Méditerranée-Infection, Aix-Marseille-Université, 27 Boulevard Jean Moulin, 13385 Marseille cedex 05, France (


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A Regional Outbreak of Clostridium difficile PCR-Ribotype 027 Infections in Southeastern France from a Single Long-Term Care Facility

  • Nadim Cassir (a1) (a2), Jean-Christophe Delarozière (a3), Gregory Dubourg (a1), Marion Delord (a2), Jean-Christophe Lagier (a1) (a2), Phillipe Brouqui (a1) (a2), Florence Fenollar (a1), Didier Raoult (a1) and Pierre Edouard Fournier (a1)...


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