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A Multicenter Study on Optimizing Piperacillin-Tazobactam Use: Lessons on Why Interventions Fail

  • Robert P. Gaynes (a1) (a2) (a3), Carolyn V. Gould (a1) (a2), Jonathan Edwards (a1), Theresa L. Antoine (a1), Henry M. Blumberg (a2) (a4), Kathryn DeSilva (a3), Mark King (a2) (a4), Alice Kraman (a5), Jan Pack (a6), Bruce Ribner (a2) (a6), Ulrich Seybold (a7), James Steinberg (a2) (a5) and John A. Jernigan (a1) (a2)...


We examined interventions to optimize piperacillin-tazobactam use at 4 hospitals. Interventions for rotating house staff did not affect use. We could target empiric therapy in only 35% of cases. Because prescribing practices seemed to be institution specific, interventions should address attitudes of local prescribers. Interventions should target empiric therapy and ordering of appropriate cultures.


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Centers for Disease Control and Prevention, 1600 Clifton Road NE, Mailstop A-24, Atlanta, GA 30333 (


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