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Molecular and epidemiologic investigation of a rhinovirus outbreak in a neonatal intensive care unit

  • Kenza Rahmouni El Idrissi (a1), Sandra Isabel (a2), Julie Carbonneau (a3), Martine Lafond (a4), Caroline Quach (a5), Chelsea Caya (a6), Patricia S. Fontela (a6) (a7) (a8), Marc Beltempo (a6) (a7), Guy Boivin (a3), Marie-Astrid Lefebvre (a4) (a7) and Jesse Papenburg (a6) (a7) (a8)...

Abstract

We performed a molecular and epidemiologic study of a healthcare-associated rhinovirus outbreak to better understand transmission in neonatal intensive care settings. Sequencing of the 7 outbreak strains revealed 4 distinct clades, indicating multiple sources. A single clade infected 3 patients in adjacent rooms, suggesting horizontal transmission. We observed 1 rhinovirus-associated death.

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Corresponding author

Author for correspondence: Jesse Papenburg MD, MSc, Montreal Children’s Hospital 1001 Décarie Blvd, Room E05 1905, Montreal, QC, H4A 3J1. E-mail: Jesse.papenburg@mcgill.ca

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PREVIOUS PRESENTATION: These study results were presented during a poster session at the Pediatric Academic Societies Meeting on May 6, 2018, in Toronto, Canada.

Cite this article: Rahmouni El Idrissi K, Isabel S, Carbonneau J, Lafond M, Quach C, Caya C, Fontela PS, Beltempo M, Boivin G, Lefebvre M-A, Papenburg J. (2019) Molecular and epidemiologic investigation of a rhinovirus outbreak in a neonatal intensive care unit. Infection Control & Hospital Epidemiology 2019, 40, 245–247. doi: 10.1017/ice.2018.311

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1. Reese, SM, Thompson, M, Price, CS, Young, HL. Evidence of nosocomial transmission of human rhinovirus in a neonatal intensive care unit. Am J Infect Control 2016;44:355357.
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3. Reid, AB, Anderson, TL, Cooley, L, Williamson, J, Mcgregor, AR. An outbreak of human rhinovirus species C infections in a neonatal intensive care unit. Pediatr Infect Dis J 2011;30:10951096.
4. Marcone, DN, Carballal, G, Irañeta, M, Rubies, Y, Vidaurreta, SM, Echavarría, M. Nosocomial transmission and genetic diversity of rhinovirus in a neonatal intensive care unit. J Pediatr 193:252255.
5. Greninger, AL, Waghmare, A, Adler, A, et al. Rule-out outbreak: 24-hour metagenomic next-generation sequencing for characterizing respiratory virus source for infection prevention. J Pediatr Infect Dis Soc 2017;6:168172.
6. AlGhounaim, M, Xiao, Y, Caya, C, Papenburg, J. Diagnostic yield and clinical impact of routine cell culture for respiratory viruses among children with a negative multiplex RT-PCR result. J Clin Virol 2017;94:107109.
7. Kumar, S, Stecher, G, Tamura, K. MEGA7: Molecular Evolutionary Genetics Analysis version 7.0 for bigger datasets. Molec Biol Evol 2016;33:18701874.
8. Julian, S, Burnham, CA, Sellenriek, P, et al. Impact of neonatal intensive care bed configuration on rates of late-onset bacterial sepsis and methicillin-resistant Staphylococcus aureus colonization. Infec Control Hosp Epidemiol 2015;36:11731182.
9. Zinna, S, Lakshmanan, A, Tan, S, et al. Outcomes of nosocomial viral respiratory infections in high-risk neonates. Pediatrics 2016;138.
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