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Identification of four patients with colistin-resistant Escherichia coli containing the mobile colistin resistance mcr-1 gene from a single health system in Michigan

  • Oryan Henig (a1), Laura J. Rojas (a2) (a3), Michael A. Bachman (a4), Susan D. Rudin (a2) (a3), Brenda M. Brennan (a5), Marty K. Soehnlen (a6), Kelly L. Jones (a6), John P. Mills (a7), Carey R. Dombecki (a8), Amanda M. Valyko (a8), Steven H. Marshall (a2) (a3) (a9), Robert A. Bonomo (a3) (a9) (a10), Keith S. Kaye (a7) and Laraine Washer (a1) (a8)...

Abstract

Clinical Enterobacteriacae isolates with a colistin minimum inhibitory concentration (MIC) ≥4 mg/L from a United States hospital were screened for the mcr-1 gene using real-time polymerase chain reaction (RT-PCR) and confirmed by whole-genome sequencing. Four colistin-resistant Escherichia coli isolates contained mcr-1. Two isolates belonged to the same sequence type (ST-632). All subjects had prior international travel and antimicrobial exposure.

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Corresponding author

Author for correspondence: Laraine Washer, Email: laraine@med.umich.edu

References

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