Hostname: page-component-848d4c4894-8kt4b Total loading time: 0 Render date: 2024-06-22T13:43:10.875Z Has data issue: false hasContentIssue false
  • English
  • Français

Contamination of Peripheral Hematopoeitic Stem Cell Products With a Mycobacterium mucogenicum–Related Pathogen

Published online by Cambridge University Press:  02 January 2015

Imad Kassis ,
Ilana Oren ,
Sima Davidson ,
Renato Finkelstein ,
Galit Rabino ,
Tami Katz  and
Hannah Sprecher
Imad Kassis*
Affiliation:
Infectious Diseases Unit, Rambam Medical Center and Bruce-Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
Ilana Oren
Affiliation:
Infectious Diseases Unit, Rambam Medical Center and Bruce-Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
Sima Davidson
Affiliation:
Microbiology Laboratory, Rambam Medical Center and Bruce-Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
Renato Finkelstein
Affiliation:
Infectious Diseases Unit, Rambam Medical Center and Bruce-Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
Galit Rabino
Affiliation:
Infectious Diseases Unit, Rambam Medical Center and Bruce-Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
Tami Katz
Affiliation:
Department of Hematology, Rambam Medical Center and Bruce-Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
Hannah Sprecher
Affiliation:
Microbiology Laboratory, Rambam Medical Center and Bruce-Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
*
Infectious Diseases Unit, Meyer Children's Hospital, Rambam Medical Center, Haifa 31096, PO Box 9602, Israel (i_kassis@rambam.health.gov.il)
Get access Rights & Permissions [Opens in a new window]

Abstract

A gram-positive rod with a restriction pattern closely related to the published nucleotide sequence of Mycobacterium mucogenicum was isolated from 6 of 45 units of peripheral blood stem cell products. The source of the contamination was traced to ice cubes used in processing the peripheral blood stem cell products. Substituting reusable ice trays for ice from an ice machine terminated the outbreak.

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 28 , Issue 6 , June 2007 , pp. 755 - 757
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2007

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Foundation for the Accreditation of Hematopoietic Cell Therapy. Standards for Hematopoietic Progenitor Cell Collection, Processing and Transplantation. 1st ed. North America. Omaha, NE: FAHCT Accreditation Office; 1996:1–58.Google Scholar
2.Smith, D, Bradley, S, Scott, G. Bacterial contamination of autologous bone marrow during processing. J Hosp Infect 1996;33:71–76.CrossRefGoogle ScholarPubMed
3.Farrington, M, Matthews, I, Jestice, HK, et al.Bacterial contamination of autologous bone marrow during processing. J Hosp Infect 1996;34:230–232.Google Scholar
4.Attarian, H, Bensinger, WI, Buckner, CD, et al.Microbial contamination of peripheral blood stem cell collections. Bone Marrow Transplant 1996;17:699–702.Google ScholarPubMed
5.Padley, D, Koontz, F, Trigg, ME, et al.Bacterial contamination rates following processing of bone marrow and peripheral blood progenitor cell preparations. Transfusion 1996;36:53–56.Google Scholar
6.Prince, H, Page, SR, Keating, A, et al.Microbial contamination of harvested bone marrow and peripheral blood. Bone Marrow Transplant 1995;15:87–91.Google Scholar
7.Lazarus, HM, Magalhaes-Silverman, M, Fox, RM, et al.Contamination during in vitro processing of bone marrow for transplantation: clinical significance. Bone Marrow Transplant 1991;7:241–246.Google Scholar
8.Gagnon, JA, Porter, K, Guerin, D, Gluck, S. Bacterial decontamination of blood stem cell apheresis products. J Clin Apheresis 1998;13:103–107.Google Scholar
9.Nasser, R, Hajjar, I, Sandhaus, LM, et al.Routine cultures of bone marrow and peripheral stem cell harvests: clinical impact, cost analysis, and review. Clin Infect Dis 1998;27:886–888.CrossRefGoogle Scholar
10.Hirji, Z, Saragosa, R, Dedier, H, et al.Contamination of bone marrow products with actinomycete resembling Microbacterium species and rein-fusion into autologous stem cell and bone marrow transplant recipients. Clin Infect Dis 2003;36:e116–e121.CrossRefGoogle ScholarPubMed
11.Steingrube, VA, Gibson, JL, Brown, BA, et al.PCR amplification and restriction endonuclease analysis of 65-kilodalton heat shock protein gene sequence for taxonomic separation of rapidly growing mycobacteria [published correction appears in J Clin Microbiol 1995;33:1686]. J Clin Microbiol 1995;33:149–153.CrossRefGoogle ScholarPubMed
12.Hall, L, Doerr, KA, Wohlfiel, SL, Roberts, GD. Evaluation of the MicroSeq system for identification of mycobacteria by 16S ribosomal DNA sequencing and its integration into a routine clinical mycobacteriology laboratory. J Clin Microbiol 2003;41:1447–1453.Google Scholar
13.Hughes, VM, Stevenson, K, Sharp, JM. Improved preparation of high molecular weight DNA for pulsed-field gel electrophoresis from mycobacteria. J Microbiol Methods 2001;44:209–215.Google Scholar
14.Cordonnier, C, Martino, R, Trabasso, P, et al.Mycobacterial infection: a difficult and late diagnosis in stem cell transplant recipients. Clin Infect Dis 2004;38:1229–1235.Google Scholar
15.Tortoli, E. Impact of genotypic studies on mycobacteria taxonomy: the new mycobacteria of the 1990s. Clin Microbiol Rev 2003;16:319–354.CrossRefGoogle ScholarPubMed
16.Springer, B, Bottger, EC, Kirschner, P, Wallace, RJ Jr. Phylogeny of Mycobacterium chelonae-like organism based on partial sequencing of the 16S rRNA gene and proposal of Mycobacterium mucogenicum sp. nov. Int J Syst Bacteriol 1995;45:262–267.CrossRefGoogle ScholarPubMed
17.Kline, S, Cameron, S, Streifel, A, et al.An outbreak of Bacteremias associated with Mycobacterium mucogenicum in a hospital water supply. Infect Control Hosp Epidemiol 2004;25:1042–1049.Google Scholar