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Comparative Killing Kinetics of Methicillin-Resistant Staphylococcus aureus by Bacitracin or Mupirocin

Published online by Cambridge University Press:  02 January 2015

Edward K. Chapnick ,
Jeremy D. Gradon ,
Barry Kreiswirth ,
Larry I. Lutwick ,
Benjamin C. Schaffer ,
Thomas D. Schiano  and
Michael H. Levi
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Abstract

The in vitro activities of bacitracin and mupirocin were compared for seven different strains of methicillin-resistant Staphylococcus aureus. Six of seven strains showed bacitracin minimum inhibitory concentrations (MICs) of 0.5 to 1.0 units/mL, and all seven had mupirocin MICs of 0.5 to 2 μg/mL. Time-kill studies revealed 2.6- to 4.5-log reduction in 24 hours with strains susceptible to bacitracin (4 units/mL) and 0 to 2.2 reduction with mupirocin (16 μg/mL). Bacitracin should be considered further for in vivo studies because of enhanced bacteriocidal effect and lower cost.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 17 , Issue 3 , March 1996 , pp. 178 - 180
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1996

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References

1.Brumfit, W, Hamilton-Miller, J. Methicillin-resistant Staphylococcus aureus. N Engl J Med 1989;320:1188–1196.Google Scholar
2.Bryan, CS, Wilson, RS, Meade, P, Sill, LG. Topical antibiotic ointments for staphylococcal nasal carriers: survey of current practices and comparison of bacitracin and vancomycin ointments. Infect Control 1980;1:153–156.Google Scholar
3.Bradley, SF, Ramsey, MA, Morton, TM, Kauffman, CA. Mupirocin resistance: clinical and molecular epidemiology. Infect Control Hosp Epidemiol 1995;16:354–358.Google Scholar
4.Frank, U, Lenz, W, Damrath, E, Kappstein, I, Daschner, FD. Nasal carriage of Staphylococcus aureus treated with topical mupirocin (pseudomonic acid) in a children's hospital. J Hosp Infect 1989;13:117–120.Google Scholar
5.Kreiswirth, BN, Kornbluth, J, Arbeit, RD, et al. Evidence for a clonal origin of methicillin resistance in Staphylococcus aureus. Science 1992;259:227–230.Google Scholar
6.Muder, RR, Brennen, C, Wagener, MM, et al. Methicillin-resistant staphylococcal colonization and infection in a long-term care facility. Ann Intern Med 1991;114:107–112.Google Scholar
7.McAnally, TP, Lewis, MR, Brown, DR. The effect of rifampin and bacitracin on nasal carriers of Staphylococcus aureus. Antimicrob Agents Chemother 1984;25:422–426.Google Scholar
8.Casewell, MW, Hill, RLR. In-vitro activity of mupirocin (pseudomonic acid) against clinical isolates of Staphylococcus aureus. J Antimicrob Chemother 1985;15:523–531.Google Scholar
9.Kauffman, CA, Terpenning, MS, He, X, Zarins, LT, Ramsay, MA, Jorgenson, KA. Attempts to eradicate methicillin-resistant Staphylococcus aureus from a long term care facility with the use of mupirocin ointment. Am J Med 1993;94:371–378.Google Scholar
10.Reagan, DR, Doebbeling, DN, Pfaller, MA, et al. Elimination of coincident Staphylococcus aureus nasal and hand carriage with intranasal application of mupirocin calcium ointment. Ann Intern Med 1991;114:101–106.Google Scholar