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A Cluster of Vancomycin-Resistant Enterococcus faecium in an Intensive Care Unit

  • Lynne V. Karanfil (a1), Mary Murphy (a2), Adele Josephson (a1), Robert Gaynes (a3), Laura Mandel (a2), Bertha C. Hill (a3) and Jana M. Swenson (a3)...



To describe the epidemiology of a cluster of vancomycin-resistant Enterococcus faecium (VAREC) in a cardiothoracic surgery intensive care unit.


A case series of patients identified through review of surveillance data on nosocomial infections, review of microbiologic records, and culture survey of patients in the unit.


Six patients in the cardiothoracic surgery intensive care unit had VAREC with identical antimicrobic susceptibility patterns over a 6-month period. Four patients were identified with VAREC through prospective surveillance and 2 through retrospective review. Prior vancomycin use was seen more commonly in patients with VAREC (6/6,100%) than in those without VAREC (3/12, 25%) (Fisher’s exact test, p= .01). Six of the 7 patients with prior infection developed VAREC (85.7%). A prior nosocomial infection and prior exposure to vancomycin were found to be important variables in a logistic regression analysis. VAREC also was isolated from the environment. Acombination of cohorting of patients and staff, and modifications of standard contact isolation practices eliminated the presence of VAREC from the cardiothoracic surgery intensive care unit.


The results suggest that prior administration of vancomycin, especially in the patient who develops nosocomial infection, can influence the acquisition of vancomycin-resistant enterococci and that VAREC may be transmitted from patient to patient. Using a modification of the standard infection control practice of isolation, we were able to control the spread of this resistant strain of E faecium.


Corresponding author

The Johns Hopkins Hospital, Department of Infection Control, 600 North Wolfe Street/ParkB112, Baltimore, MD 21205


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A Cluster of Vancomycin-Resistant Enterococcus faecium in an Intensive Care Unit

  • Lynne V. Karanfil (a1), Mary Murphy (a2), Adele Josephson (a1), Robert Gaynes (a3), Laura Mandel (a2), Bertha C. Hill (a3) and Jana M. Swenson (a3)...


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