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Clostridium difficile- Associated Diarrhea in a VA Medical Center Clustering of Cases, Association With Antibiotic Usage, and Impact on HIV-infected Patients

Published online by Cambridge University Press:  02 January 2015

Lona R. Mody ,
Sharon M. Smith  and
Lisa L. Dever
Lona R. Mody
Affiliation:
Department of Medicine, Veterans Affairs New Jersey Health Care System, East Orange, New Jersey; and the, UMDNJ-New Jersey Medical School, Newark, New Jersey
Sharon M. Smith
Affiliation:
Department of Laboratory Medicine and Pathology, Veterans Affairs New Jersey Health Care System, East Orange, New Jersey; and the, UMDNJ-New Jersey Medical School, Newark, New Jersey
Lisa L. Dever*
Affiliation:
Department of Medicine, Veterans Affairs New Jersey Health Care System, East Orange, New Jersey; and the, UMDNJ-New Jersey Medical School, Newark, New Jersey
*
Medical Service, VA NJ Health Care System, 385 Tremont Ave, East Orange, NJ 07018
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Abstract

A case-control study of patients with stools assayed for Clostridium difficile toxin over a 24-month period at a Veterans Affairs hospital found that the majority of cases (70.6%) occurred in temporal clusters. Clustering was particularly evident on a designated human immunodeficiency virus (RW) unit. Thirty-four (75.5%) of 45 HIV-infected patients with C difficile-associated diarrhea (CDAD) died during their hospitalization. Third-generation cephalosporins were the antibiotics most strongly associated with CDAD.

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 22 , Issue 1 , January 2001 , pp. 42 - 45
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2001

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