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Butoconazole Nitrate

Published online by Cambridge University Press:  21 June 2016

Demetris M. Tatum  and
Mark Eggleston
Demetris M. Tatum
Affiliation:
Howard University, College of Pharmacy and Pharmacol Sciences, Washington, DC
Mark Eggleston*
Affiliation:
Howard University, College of Pharmacy and Pharmacol Sciences, Washington, DC
*
Mark Eggleston, PharmD, PO Box 115, Wood-bridge. VA 22191
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Extract

Imidazoles and their derivatives have been proven very effective in the treatment of fungal infections. Butoconazole nitrate is an important addition to this class of antifungal agents. It was introduced to the market in for the short-term management of vaginal infections caused by Candida species. It has high activity, against Candida albicans in vitro and is very effective clinically.

Butoconazole nitrate is an imidazole derivative with potent antifungal activity in vivo and in vitro (Figure). When synthesized, it exists as a racemic mixture in which both components are optical isomers and equally active.

Type
Special Sections
Information
Infection Control & Hospital Epidemiology , Volume 9 , Issue 3 , March 1988 , pp. 122 - 124
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1988

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References

1. Beggs, WH: The effect of antifungal imidazoles on resting cells of Candida parapsilosis . Int Res Commun Sys J Med Sci 1983; 11:667–679.Google Scholar
2. Brown, D: Therapeutic alternatives and new treatment modalities in vulvovaginal candidiasis. J Reproduct Med 1986; 31:653–654.Google Scholar
3. Borger, M: Mechanism of action of antifungal drugs, with special reference to imidazole derivatives. Rev Infect Dis 1980; 2:520–534.CrossRefGoogle Scholar
4. Bradbeer, CS, Mayhew, SR, Barlow, D: Butoconazole and miconazole in treating vaginal candidiasis. Genitourin Med 1985; 61:270–272.Google ScholarPubMed
5. Henry, MJ, Sisler, HD: Effects of miconazole and dodecylimidazole on sterol biosynthesis in Ustilago maydis. Antimicroh Agents Chemother 1979; 15:603–607.CrossRefGoogle ScholarPubMed
6. Walker, KAM, Braemer, AC, Hitt, S, et al: 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl}-lH-imidazole nitrate, a new potent antifungal agent. J Med them 1978; 21:840–843.Google ScholarPubMed
7. Pye, GW, Marriott, MS: Inhibition of sterol C-14 demethylation by imidazole containing antifungals. Sabouraudia 1982; 20:325–329.CrossRefGoogle Scholar
8. Sud, IF, Feingold, DS: Mechanism of action of the antimyeotic imidazoles. J Invest Dermatol 1981; 76:438–441.CrossRefGoogle ScholarPubMed
9. Gardner, HL, Kaufman, RH: Benign Diseases of the Vulva and Vagina, ed 2. Boston, GK Hall Medical Publishers, 1981.Google Scholar
10. Brass, C, Galgiani, JN, Blaschke, TF, et al: Disposition of ketoconazole, an oral antifungal in humans. Antimicrob Agents Chemother 1982; 21:151–158.CrossRefGoogle ScholarPubMed
11 Brett, L: Femstat Vaginal Cream 2%. Product Summary, Syntex Laboratories, 01 1986.Google Scholar
12 Haller, I: Mode of action of clotrimazole: Implications for therapy. Am J Obstet Gynecol 1985; 152:939–944.10.1016/S0002-9378(85)80005-3CrossRefGoogle ScholarPubMed
13 Henzl, M: Metabolism of butoconazole. J Reproduct Med 1986; 31:658–659.Google Scholar
14 Droegemueller, W, Adamson, GD, Brown, D, et al: Three day treatment with butoconazole nitrate for vulvovaginal candidiasis. Obstet Gynecol 1984; 64:530–534.Google ScholarPubMed
15 Hurley, R, deLouvois, J: Candida, vaginitis. Postgrad Med J 1979; 55:645–647.CrossRefGoogle Scholar
16 Van Dyck, W: A comparative study of butoconazole, miconazole, and placebo. J Reproduct Med 1986; 32:662–663.Google Scholar
li Jacohson, JB, Hajman, AJ, Wiese, J, et al: First clinical experience with a new antifungal agent, butoconazole nitrate: A double blind comparison to miconazole nitrate. 10th World Congress of Gynecology and Obstetrics, 10 17-22, 1982, San Francisco, California. New York, Academy Professional Information Services, 1982, p 368.Google Scholar
18 Matthews, T: Butoconazole: Pharmacologic considerations, chemistry, and microbiology. J Reproduct Med 1986; 31:655–657.Google Scholar