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Antimicrobial Prescribing Practices in Response to Different Clostridium difficile Diagnostic Methodologies

  • Emily R. M. Sydnor (a1), Abigail Lenhart (a2), Brandon Trollinger (a3), Edina Avdic (a3), Lisa L. Maragakis (a1), Karen C. Carroll (a1) (a4) and Sara E. Cosgrove (a1)...


We evaluated treatment decisions and antimicrobial use related to 2 testing algorithms for Clostridium difficile infection (CDI). findings suggest that a 2-step testing algorithm using rapid polymerase chain reaction confirmatory testing leads to decreased unnecessary anti-CDI antimicrobial use. In addition, a significant proportion of patients with confirmed CDI were not treated accordingto recommended guidelines.


Corresponding author

Johns Hopkins Hospital, 600 North Wolfe Street, Osier 425, Baltimore, MD 21287 (


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