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Infection Control & Hospital Epidemiology Infection Control & Hospital Epidemiology

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Randomized Controlled Trial to Determine the Impact of Probiotic Administration on Colonization With Multidrug-Resistant Organisms in Critically Ill Patients

Published online by Cambridge University Press:  27 August 2015

Jennie H. Kwon ,
Kerry M. Bommarito ,
Kimberly A. Reske ,
Sondra M. Seiler ,
Tiffany Hink ,
Hilary M. Babcock ,
Marin H. Kollef ,
Victoria J. Fraser ,
Carey-Ann D. Burnham  and
Erik R. Dubberke
Jennie H. Kwon*
Affiliation:
Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri
Kerry M. Bommarito
Affiliation:
Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri
Kimberly A. Reske
Affiliation:
Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri
Sondra M. Seiler
Affiliation:
Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri
Tiffany Hink
Affiliation:
Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri
Hilary M. Babcock
Affiliation:
Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri
Marin H. Kollef
Affiliation:
Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, Missouri
Victoria J. Fraser
Affiliation:
Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri
Carey-Ann D. Burnham
Affiliation:
Departments of Pathology & Immunology and Pediatrics, Washington University School of Medicine, St. Louis, Missouri
Erik R. Dubberke
Affiliation:
Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri
*
Address correspondence to Jennie H. Kwon, DO, Washington University School of Medicine, Division of Infectious Diseases, 6600 S Euclid Ave, Campus Box 8051, St. Louis, MO 63110 (JKwon@dom.wustl.edu).
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Abstract

This was a randomized controlled pilot study of Lactobacillus rhamnosus GG versus standard of care to prevent gastrointestinal multidrug-resistant organism colonization in intensive care unit patients. Among 70 subjects, there were no significant differences in acquisition or loss of any multidrug-resistant organisms (P>.05) and no probiotic-associated adverse events.

Infect. Control Hosp. Epidemiol. 2015;36(12):1451–1454

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 36 , Issue 12 , December 2015 , pp. 1451 - 1454
Copyright
© 2015 by The Society for Healthcare Epidemiology of America. All rights reserved 

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References

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Randomized Controlled Trial to Determine the Impact of Probiotic Administration on Colonization With Multidrug-Resistant Organisms in Critically Ill Patients
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