Hostname: page-component-8448b6f56d-qsmjn Total loading time: 0 Render date: 2024-04-19T11:10:22.877Z Has data issue: false hasContentIssue false

Double-swab 5% versus single-swab 10% iodophor for reducing methicillin-resistant Staphylococcus aureus with routine chlorhexidine bathing

Published online by Cambridge University Press:  26 August 2021

Lauren T. Heim*
Affiliation:
Health Policy Research Institute, University of California, Irvine, California Division of Infectious Diseases, University of California, Irvine School of Medicine, Irvine, California
Loren G. Miller
Affiliation:
Harbor-UCLA Medical Center, Torrance, California
Raveena D. Singh
Affiliation:
Division of Infectious Diseases, University of California, Irvine School of Medicine, Irvine, California
James A. McKinnell
Affiliation:
Infectious Disease Clinical Outcomes Research (ID-CORE), Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California Expert Stewardship, Newport Beach, California
Tabitha D. Catuna
Affiliation:
Division of Infectious Diseases, University of California, Irvine School of Medicine, Irvine, California
Marlene Estevez
Affiliation:
Division of Infectious Diseases, University of California, Irvine School of Medicine, Irvine, California
Kaye D. Evans
Affiliation:
Department of Pathology and Laboratory Medicine, University of California, Irvine School of Medicine, Irvine, California
Tom K. Tjoa
Affiliation:
Division of Infectious Diseases, University of California, Irvine School of Medicine, Irvine, California
Gabrielle M. Gussin
Affiliation:
Division of Infectious Diseases, University of California, Irvine School of Medicine, Irvine, California
Shaun D. Dahl
Affiliation:
Alamitos Belmont Rehabilitation Hospital, Alamitos, California
Linda Budy
Affiliation:
Coventry Court Health Center, Anaheim, California
Ellena M. Peterson
Affiliation:
Department of Pathology and Laboratory Medicine, University of California, Irvine School of Medicine, Irvine, California
Susan S. Huang
Affiliation:
Health Policy Research Institute, University of California, Irvine, California Division of Infectious Diseases, University of California, Irvine School of Medicine, Irvine, California
*
Author for correspondence: Lauren T. Heim, E-mail: heiml@uci.edu

Abstract

In a prospective cohort study, we compared a 2-swabs-per-nostril 5% iodophor regimen with a 1-swab-per-nostril 10% iodophor regimen on methicillin-resistant Staphylococcus aureus carriage in nursing-home residents. Compared with baseline, both single-swab and double-swab regimens resulted in an identical 40% reduction in nasal carriage and 60% reduction in any carriage, skin or nasal.

Type
Concise Communication
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

a

Authors of equal contribution.

References

Dantes, R, Mu, Y, Belflower, R, et al. Emerging infections program–active bacterial core surveillance mrsa surveillance investigators. National burden of invasive methicillin-resistant Staphylococcus aureus infections, United States, 2011. JAMA Intern Med 2013;173:19701978.Google Scholar
Huang, SS, Singh, R, McKinnell, JA, et al. Project CLEAR trial. Decolonization to reduce postdischarge infection risk among MRSA carriers. N Engl J Med 2019;380:638650.CrossRefGoogle ScholarPubMed
Perl, TM, Cullen, JJ, Wenzel, RP, et al. Mupirocin and the risk of Staphylococcus aureus study team. Intranasal mupirocin to prevent postoperative Staphylococcus aureus infections. N Engl J Med 2002;346:18711877.CrossRefGoogle Scholar
von Eiff, C, Becker, K, Machka, K, Stammer, H, Peters, G. Nasal carriage as a source of Staphylococcus aureus bacteremia. Study Group. N Engl J Med 2001;344:1116.CrossRefGoogle ScholarPubMed
van Rijen, M, Bonten, M, Wenzel, R, Kluytmans, J. Mupirocin ointment for preventing Staphylococcus aureus infections in nasal carriers. Cochrane Database Syst Rev 2008;(4):CD006216.Google ScholarPubMed
Deshpande, LM, Fix, AM, Pfaller, MA, Jones, RN; SENTRY antimicrobial surveillance program participants group. Emerging elevated mupirocin resistance rates among staphylococcal isolates in the SENTRY Antimicrobial Surveillance Program (2000): Correlations of results from disk diffusion, etest and reference dilution methods. Diagn Microbiol Infect Dis 2002;42:283290.CrossRefGoogle Scholar
Richter, SS, Diekema, DJ, Heilmann, KP, et al. Activities of vancomycin, ceftaroline, and mupirocin against Staphylococcus aureus isolates collected in a 2011 national surveillance study in the United States. Antimicrob Agents Chemother 2014;58:740745.Google Scholar
Phillips, M, Rosenberg, A, Shopsin, B, et al. Preventing surgical site infections: a randomized, open-label trial of nasal mupirocin ointment and nasal povidone–iodine solution. Infect Control Hosp Epidemiol 2014;35:826832.CrossRefGoogle ScholarPubMed
McKinnell, JA, Miller, LG, Singh, R, et al. Prevalence of and factors associated with Multidrug Resistant Organism (MDRO) colonization in 3 nursing homes. Infect Control Hosp Epidemiol 2016 Dec;37:14851488.CrossRefGoogle ScholarPubMed
Mermel, LA, Machan, JT, Parenteau, S. Seasonality of MRSA infections. PLoS One 2011;6(3):e17925.CrossRefGoogle ScholarPubMed