Skip to main content Accessibility help
×
Home
Hostname: page-component-5bf98f6d76-slc4r Total loading time: 8.38 Render date: 2021-04-21T06:02:02.414Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": false, "newCiteModal": false, "newCitedByModal": true }

Community-Acquired Infection With Healthcare-Associated Methicillin-Resistant Staphylococcus aureus: The Role of Home Nursing Care

Published online by Cambridge University Press:  21 June 2016

François-Xavier Lescure
Affiliation:
Departments of Tropical and Infectious Diseases, Hospital and University Centre, Amiens, France Service de maladies infectieuses et tropicales, Hôpital Tenon, Paris, France
Gwenaelle Locher
Affiliation:
Bacteriology, Hospital and University Centre, Amiens, France
Mathieu Eveillard
Affiliation:
Bacteriology, Hospital and University Centre, Amiens, France
Maurice Biendo
Affiliation:
Bacteriology, Hospital and University Centre, Amiens, France
Stéphanie Van Agt
Affiliation:
Bacteriology, Hospital and University Centre, Amiens, France
Guillaume Le Loup
Affiliation:
Departments of Tropical and Infectious Diseases, Hospital and University Centre, Amiens, France
Youcef Douadi
Affiliation:
Departments of Tropical and Infectious Diseases, Hospital and University Centre, Amiens, France
Olivier Ganry
Affiliation:
Epidemiology, Hospital and University Centre, Amiens, France
François Vandenesch
Affiliation:
INSERM E0230, IFR62, Centre National de Référence des Staphylocoques, Faculté de Médecine Laennec, Lyon, France
François Eb
Affiliation:
Bacteriology, Hospital and University Centre, Amiens, France
Jean-Luc Schmit
Affiliation:
Departments of Tropical and Infectious Diseases, Hospital and University Centre, Amiens, France
Jerome Etienne
Affiliation:
INSERM E0230, IFR62, Centre National de Référence des Staphylocoques, Faculté de Médecine Laennec, Lyon, France
Corresponding

Abstract

Objective.

To better understand the role of indirect transmission in community-acquired infection with methicillin-resistant Staphylococcus aureus (MRSA).

Design.

Prospective case-control study.

Setting.

A French teaching hospital.

Patients.

A total of 198 case patients and 198 control patients with MRSA or methicillin-susceptible S. aureus infection diagnosed between April 2002 and July 2003.

Results.

Multivariate analysis showed a highly significant independent link between MRSA infection at admission and prior receipt of home nursing care (odds ratio [OR], 3.7; P<.001). Other independent risk factors were prior hospitalization (OR, 3.8; P<.001), transfer from another institution (OR, 2.3; P = .008), and age older than 65 years (OR, 1.6; P = .04). Prior home nursing care showed a frequency dose-response relationship. Eleven MRSA-infected patients had had home nursing procedures but no hospital stay in the previous 3 years. These patients' MRSA strains were related to the prevalent MRSA clone currently spreading in French hospitals.

Conclusion.

Home nursing care appears to be an independent risk factor for MRSA acquisition in the community. The reservoir probably consists of MRSA carriers discharged from the hospital. Community nurses seem to be a potential vector.

Type
Original Articles
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2006

Access options

Get access to the full version of this content by using one of the access options below.

References

1. Tiemersma, EW, Bronzwaer, SL, Lyytikainen, O, et al. Methicillin-resistant Staphylococcus aureus in Europe, 1999-2002. Emerg Infect Dis 2004; 10:16271634.CrossRefGoogle Scholar
2. Heym, B, Le Moal, M, Armand-Lefevre, L, Nicolas-Chanoine, MH. Multilocus sequence typing (MLST) shows that the ‘Iberian’ clone of methicillin-resistant Staphylococcus aureus has spread to France and acquired reduced susceptibility to teicoplanin. J Antimicrob Chemother 2002; 50:323329.CrossRefGoogle ScholarPubMed
3. Oliveira, DC, Tomasz, A, de Lencastre, H. Secrets of success of a human pathogen: molecular evolution of pandemic clones of methicillin-resistant Staphylococcus aureus . Lancet Infect Dis 2002; 2:180189.CrossRefGoogle Scholar
4. Vandenesch, F, Naimi, T, Enright, MC, et al. Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence. Emerg Infect Dis 2003; 9:978984.CrossRefGoogle ScholarPubMed
5. Francis, JS, Doherty, MC, Lopatin, U, et al. Severe community-onset pneumonia in healthy adults caused by methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin genes. Clin Infect Dis 2005; 40:100107.CrossRefGoogle ScholarPubMed
6. Naimi, TS, LeDell, KH, Como-Sabetti, K, et al. Comparison of community-and health care-associated methicillin-resistant Staphylococcus aureus infection. JAMA 2003; 290:29762984.CrossRefGoogle ScholarPubMed
7. Salgado, CD, Farr, BM, Calfee, DP. Community-acquired methicillin-resistant Staphylococcus aureus: a meta-analysis of prevalence and risk factors. Clin Infect Dis 2003; 36:131139.CrossRefGoogle ScholarPubMed
8. Charlebois, ED, Bangsberg, DR, Moss, NJ, et al. Population-based community prevalence of methicillin-resistant Staphylococcus aureus in the urban poor of San Francisco. Clin Infect Dis 2002; 34:425433.CrossRefGoogle ScholarPubMed
9. Abudu, L, Blair, I, Fraise, A, Cheng, KK. Methicillin-resistant Staphylococcus aureus (MRSA): a community-based prevalence survey. Epidemiol Infect 2001; 126:351356.CrossRefGoogle ScholarPubMed
10. Hussain, FM, Boyle-Vavra, S, Bethel, CD, Daum, RS. Current trends in community-acquired methicillin-resistant Staphylococcus aureus at a tertiary care pediatric facility. Pediatr Infect Dis J 2000; 19:11631166.CrossRefGoogle Scholar
11. Rezende, NA, Blumberg, HM, Metzger, BS, Larsen, NM, Ray, SM, McGowan, JE Jr. Risk factors for methicillin-resistance among patients with Staphylococcus aureus bacteremia at the time of hospital admission. Am J Med Sci 2002; 323:117123.CrossRefGoogle ScholarPubMed
12. Troillet, N, Carmeli, Y, Samore, MH, et al. Carriage of methicillin-resistant Staphylococcus aureus at hospital admission. Infect Control Hosp Epidemiol 1998; 19:181185.CrossRefGoogle ScholarPubMed
13. Shopsin, B, Mathema, B, Martinez, J, et al. Prevalence of methicillin-resistant and methicillin-susceptible Staphylococcus aureus in the community. J Infect Dis 2000; 182:359362.CrossRefGoogle Scholar
14. Calfee, DP, Durbin, LJ, Germanson, TP, Toney, DM, Smith, EB, Farr, BM. Spread of methicillin-resistant Staphylococcus aureus (MRSA) among household contacts of individuals with nosocomially acquired MRSA. Infect Control Hosp Epidemiol 2003; 24:422426.CrossRefGoogle ScholarPubMed
15. Lesens, O, Hansmann, Y, Brannigan, E, et al. Healthcare-associated Staphylococcus aureus bacteremia and the risk for methicillin resistance: is the Centers for Disease Control and Prevention definition for community-acquired bacteremia still appropriate? Infect Control Hosp Epidemiol 2005; 26:204209.CrossRefGoogle ScholarPubMed
16. Friedman, ND, Kaye, KS, Stout, JE, et al. Health care–associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections. Ann Intern Med 2002; 137:791797.CrossRefGoogle ScholarPubMed
17. Eveillard, M, Martin, Y, Hidri, N, Boussougant, Y, Joly-Guillou, ML. Carriage of methicillin-resistant Staphylococcus aureus among hospital employees: prevalence, duration, and transmission to households. Infect Control Hosp Epidemiol 2004; 25:114120.CrossRefGoogle ScholarPubMed
18. Wagenvoort, JH, De Brauwer, EI, Sijstermans, ML, Toenbreker, HM. Risk of re-introduction of methicillin-resistant Staphylococcus aureus into the hospital by intrafamilial spread from and to healthcare workers. J Hosp Infect 2005; 59:6768.CrossRefGoogle ScholarPubMed
19. Comité de l'Antibiogramme de la Société Française de Microbiologie. Zone sizes and IMC break-points and non-fastidious organisms. Clin Microbiol Infect 1996; 2(Suppl 1):S1S49.Google Scholar
20. Goering, RV, Winters, MA. Rapid method for epidemiological evaluation of gram-positive cocci by field inversion gel electrophoresis. J Clin Microbiol 1992; 30:577580.Google ScholarPubMed
21. Enright, MC, Day, NP, Davies, CE, Peacock, SJ, Spratt, BG. Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus . J Clin Microbiol 2000; 38:10081015.Google ScholarPubMed
22. Jarraud, S, Mougel, C, Thioulouse, J, et al. Relationships between Staphylococcus aureus genetic background, virulence factors, agr groups (alleles), and human disease. Infect Immun 2002; 70:631641.CrossRefGoogle Scholar
23. Oliveira, DC, de Lencastre, H. Multiplex PCR strategy for rapid identification of structural types and variants of the mec element in methicillin-resistant Staphylococcus aureus . Antimicrob Agents Chemother 2002; 46:21552161.CrossRefGoogle ScholarPubMed
24. Lemeshow, S, Hosmer, DW Jr. A review of goodness of fit statistics for use in the development of logistic regression models. Am J Epidemiol 1982; 115:92106.CrossRefGoogle ScholarPubMed
25. Tambyah, PA, Habib, AG, Ng, TM, Goh, H, Kumarasinghe, G. Community-acquired methicillin-resistant Staphylococcus aureus infection in Singapore is usually “healthcare associated”. Infect Control Hosp Epidemiol 2003; 24:436438.CrossRefGoogle ScholarPubMed
26. Pittet, D, Dharan, S, Touveneau, S, Sauvan, V, Perneger, TV. Bacterial contamination of the hands of hospital staff during routine patient care. Arch Intern Med 1999; 159:821826.CrossRefGoogle ScholarPubMed
27. MacKinnon, MM, Allen, KD. Long-term MRSA carriage in hospital patients. J Hosp Infect 2000; 46:216221.CrossRefGoogle ScholarPubMed
28. Stefani, S, Varaldo, PE. Epidemiology of methicillin-resistant staphylococci in Europe. Clin Microbiol Infect 2003; 9:11791186.CrossRefGoogle Scholar
29. Chambers, HF. The changing epidemiology of Staphylococcus aureus? Emerg Infect Dis 2001; 7:178182.CrossRefGoogle ScholarPubMed

Altmetric attention score

Full text views

Full text views reflects PDF downloads, PDFs sent to Google Drive, Dropbox and Kindle and HTML full text views.

Total number of HTML views: 0
Total number of PDF views: 3 *
View data table for this chart

* Views captured on Cambridge Core between September 2016 - 21st April 2021. This data will be updated every 24 hours.

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Community-Acquired Infection With Healthcare-Associated Methicillin-Resistant Staphylococcus aureus: The Role of Home Nursing Care
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

Community-Acquired Infection With Healthcare-Associated Methicillin-Resistant Staphylococcus aureus: The Role of Home Nursing Care
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

Community-Acquired Infection With Healthcare-Associated Methicillin-Resistant Staphylococcus aureus: The Role of Home Nursing Care
Available formats
×
×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *