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Tests for an effect of the Y-chromosome on the mutagenic action of formaldehyde and X-rays in Drosophila melanogaster

Published online by Cambridge University Press:  14 April 2009

Winston E. Ratnayake
Affiliation:
Institute of Genetics, Edinburgh, 9

Extract

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An additional Y-chromosome in either male or female did not have an influence on the mutagenic action of formaldehyde–food. It is concluded that the lack of response of female germs cells to this treatment is not due to lack of a Y-chromosome, and that the specific response of spermatocytes among germ cells is probably not due to the striking activity of the Y in these cells.

Kershner's (1949) observation that the sex-linked lethal frequency in X-rayed males was significantly reduced by an additional Y-chromosome could not be confirmed.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1968

References

REFERENCES

Alderson, T. (1961). Mechanism of mutagenesis induced by formaldehyde: The essential role of the 6-amino group of adenylic acid (or adenosine) in the mediation of the mutagenic activity of formaldehyde. Nature, Lond. 191, 251253.CrossRefGoogle ScholarPubMed
Auerbach, C. & Moser, H. (1953). An analysis of the mutagenic action of formaldehyde–food. I. Sensitivity of Drosophila germ cells. Z. indukt. Abstamm. -u. Vererb Lehre 85, 479504.Google ScholarPubMed
Herskowitz, I. H. (1950). The differential induction of lethal mutations by formalin in the sexes of Drosophila. Science, N.Y. 112, 302303.CrossRefGoogle ScholarPubMed
Hess, O. (1966). Structural modifications of the Y chromosome in Drosophila hydei and their relation to gene activity. In Chromosomes Today, vol. I, pp. 167173. Ed. Darlington, and Lewis, .Google Scholar
Hess, O. & Meyer, G. F. (1963). Chromosomal differentiation of the lampbrush type formed by the Y chromosome in Drosophila hydei and D. neohydei. J. Cell. Biol. 16, 527539.CrossRefGoogle Scholar
Kaplan, W. D. & Pelc, S. R. (1956). Autoradiographic studies of Drosophila gonads following the feeding of C14-labelled formaldehyde. Z. indukt. Abstamm. -u. Vererb Lehre 87, 356364.Google Scholar
Kelsall, P. (1963). Non-disjunction and maternal age in Drosophila melanogaster. Genet. Res. 4, 284289.CrossRefGoogle Scholar
Kershner, J. (1949). The influence of the Y-chromosome in X-ray induced mutation rate in D. melanogaster. Pro. U.S. nain. Acad. Sci. U.S.A. 35, 647652.CrossRefGoogle Scholar
Nafei, H. & Auerbach, C. (1964). Mutagenesis by formaldehyde food in relation to DNA replication in Drosophila spermatozoa. Z. indukt. Abstamm. -u. Vererb Lehre 95, 351367.Google Scholar
Sobels, F. H. (1956). Studies on the mutagenic action of formaldehyde in Drosophila. II. The production of mutations in the females and the induction of crossing over. Z. indukt. Abstamm. -u. VererbLehre 87, 743752.Google ScholarPubMed
Sobels, F. H. & Simons, J. W. I. M. (1956). Studies on the mutagenic action of formaldehyde in Drosophila. I. The effect of pretreatment with cyanide on the mutagenicity of formaldehyde and of formaldehyde-hydrogen peroxide mixtures in males. Z. indukt. Abstamm. -u. Vererb Lehre 87, 735742.Google ScholarPubMed
Valencia, J. I. & Valencia, R. M. (1951). The ineffectiveness of extra heterochromatin in influencing mutation, rate in the female. Drosoph. Inf. Serv. 25, 131132.Google Scholar