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The site of action of the asebia locus (ab) in the skin of the mouse

Published online by Cambridge University Press:  14 April 2009

Pamela R. Pennycuik ,
Kathryn A. Raphael ,
R. E. Chapman  and
Margaret H. Hardy
Pamela R. Pennycuik
Affiliation:
CSIRO, Division of Animal Production, P.O. Box 239, Blacktown, N.S.W., 2148, Australia
Kathryn A. Raphael
Affiliation:
CSIRO, Division of Animal Production, P.O. Box 239, Blacktown, N.S.W., 2148, Australia
R. E. Chapman
Affiliation:
CSIRO, Division of Animal Production, P.O. Box 239, Blacktown, N.S.W., 2148, Australia
Margaret H. Hardy
Affiliation:
CSIRO, Division of Animal Production, P.O. Box 239, Blacktown, N.S.W., 2148, Australia
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In mice homozygous for the asebia mutation (abJ/abJ) the sebaceous glands were small and the sebaceous cells abnormal, the fully grown hair follicles were twice as long as those in wild-type (+ / +) mice, the catagen and telogen follicles were abnormal and, because the active phase of the hair cycle was longer than in + / + mice, the initiation of the second hair cycle was delayed. The abnormalities in the sebaceous glands and in catagen and telogen follicles were also present in abJ/abJ embryonic skin grown on a nude host but anagen of the second hair cycle commenced at about the same time in abJ / abJ and + / + grafts. When recombinants incorporating mutant or wild-type epidermis and dermis were grown on a nude host, the abnormalities in the sebaceous glands and the catagen and telogen follicles were only observed in the recombinants incorporating abJ / abJ epidermis. It was concluded that mutant activity in the epidermis was responsible for the abnormalities in the sebaceous glands and in catagen and telogen follicles and that mutant activity at some site distant from the skin was responsible for the abnormalities in the timing of the hair cycles.

Type
Research Article
Information
Genetics Research , Volume 48 , Issue 3 , December 1986 , pp. 179 - 185
Copyright
Copyright © Cambridge University Press 1986

References

Billingham, R. E. & Silvers, W. K. (1973). Transplantation and cutaneous genetics. Journal of Investigative Dermatology 60, 509–515.Google Scholar
Carter, H. B. & Clarke, W. H. (1957). The hair follicle group and skin follicle population of Australian Merino sheep. Australian Journal of Agricultural Research 8, 91–108.Google Scholar
Chase, H. B., Montagna, W. & Malone, J. D. (1953). Changes in the skin in relation to the hair growth cycle. Anatomical Record 116, 75–81.CrossRefGoogle Scholar
Fisher, C., Dale, B. A. & Kollar, E. J. (1984). Abnormal keratinization in the pupoid fetus (pf/pf) mutant mouse epidermis. Developmental Biology 102, 290–299.CrossRefGoogle ScholarPubMed
Gates, A. H. & Karasek, M. (1965). Hereditary absence of sebaceous glands in the mouse. Science 148, 1471–1473.CrossRefGoogle ScholarPubMed
Gemmell, R. T. & Chapman, R. E. (1971). Formation and breakdown of the inner root sheath and features of the pilary canal epithelium in the wool follicle. Journal of Ultrastructure Research 36, 355–366.Google Scholar
Green, M. C., Alpert, B. N. & Mayer, T. C. (1974). The site of action of the ichthyosis locus (ic) in the mouse, as determined by dermal–epidermal recombinations. Journal of Embryology and Experimental Morphology 32, 715–721.Google ScholarPubMed
Grüneberg, H. (1971). The Tabby syndrome in the mouse. Proceedings of the Royal Society of London B179, 139–156.Google Scholar
Halmi, N. S. & Davies, J. (1953). Comparison of aldehyde fuchsin staining, metachromasia and periodic acid–Schiff reactivity of various tissues. Journal of Histochemistry and Cytochemistry 1, 447–459.CrossRefGoogle ScholarPubMed
Hardy, M. H. (1949). The development of mouse hair in vitro with some observations on pigmentation. Journal of Anatomy 83, 364–384.Google Scholar
Hardy, M. H. (1951). The development of pelage hairs and vibrissae from skin in tissue culture. Annals of the New York Academy of Science 53, 546–561.Google Scholar
Hardy, M. H. (1969). The differentiation of hair follicles and hairs in organ culture. In Advances in Biology of Skin volume ix; Hair Growth (ed. Montagna, W. and Dobson, R. L.), pp. 35–60. Oxford and New York: Pergamon Press.Google Scholar
Josefowicz, W. J. (1975). The Development and Expression of the Asebia Mutation in Mice. MSc Thesis, University of Guelph.Google Scholar
Josefowicz, W. J. & Hardy, M. H. (1974). The development and expression of the mutation asebia (ab/ab) in mice. Proceedings of the Canadian Federation of Biological Sciences 17, 173.Google Scholar
Josefowicz, W. J. & Hardy, M. H. (1978 a). The expression of the gene asebia in the laboratory mouse. I. Epidermis and dermis. Genetical Research 31, 53–65.CrossRefGoogle ScholarPubMed
Josefowicz, W. J. & Hardy, M. H. (1978 b). The expression of the gene asebia in the laboratory mouse. 2. Hair follicles. Genetical Research 31, 145–155.Google Scholar
Josefowicz, W. J. & Hardy, M. H. (1978 c). The expression of the gene asebia in the laboratory mouse. 3. Sebaceous glands. Genetical Research 31, 157–166.CrossRefGoogle Scholar
Kindred, B. (1967). Some observations on the skin and hair of Tabby mice. Journal of Heredity 58, 197–199.Google Scholar
McManus, J. F. A. & Mowry, R. W. (1965). Staining Methods, Histological and Histochemical. New York: Evanston, London: Harper and Row.Google Scholar
Mayer, T. C., Miller, C. K. & Green, M. C. (1977). Site of action of the crinkled (cr) locus in the mouse. Developmental Biology 55, 397–401.CrossRefGoogle ScholarPubMed
Mohn, M. P. (1958). The effects of different hormonal states on the growth of hair in rats. In The Biology of Hair Growth (ed. Montagna, W. and Ellis, R. A.), pp. 335–398. New York: Academic Press.Google Scholar
Montagna, W. & Parakkal, P. F. (1974). The Structure and Function of Skin, 3rd edition. New York: Academic Press.Google Scholar
Nay, T. (1960). Growth of the mouse coat. VII. Hair cycles and sebaceous glands in homozygous and heterozygous naked mice. Australian Journal of Biological Sciences 13, 351–355.Google Scholar
Nay, T. (1972). Hair of asebic mice. Mouse News Letter 46, 40.Google Scholar
Parakkal, P. F. (1970). Morphogenesis of the hair follicle during catagen. Zeitschrift für Zellforschung und mikroskopische Anatomie 107, 174–186.Google Scholar
Pennycuik, P. R. & Raphael, K. A. (1984 a). The tabby locus (Ta) in the mouse: its site of action in tail and body skin. Genetical Research 43, 51–63.CrossRefGoogle ScholarPubMed
Pennycuik, P. R. & Raphael, K. A. (1984 b). The angora locus (go) in the mouse: hair morphology, duration of growth cycle and site of action. Genetical Research 44, 283–291.Google Scholar
Raphael, K. A. & Pennycuik, P. R. (1980). The site of action of the naked locus (N) in the mouse as determined by dermal–epidermal recombinations. Journal of Embryology and Experimental Morphology 57, 143–153.Google Scholar
Slee, J. (1957). The morphology and development of ‘Ragged’ – a mutant affecting the skin and hair of the house mouse, a, Adult morphology. Journal of Genetics 55, 100–121.Google Scholar
Straile, W. E. (1965). Root sheath–dermal papilla relationships and the control of hair growth. In Biology of Skin and Hair Growth (ed. Lyne, A. G. and Short, B. F.), pp. 35–37. Sydney: Angus & Robertson.Google Scholar
Straile, W. E., Chase, H. B. & Arsenault, C. (1961). Growth and differentiation of hair follicles between periods of activity and quiescence. Journal of Experimental Zoology 148, 205–222.Google Scholar
Theriault, L. L., Dugan, D. D., Simons, S., Keen, C. L. & Hurley, L. S. (1977). Lipid and myelin abnormalities of brain in the crinkled mouse. Proceedings of the Society of Experimental Biology and Medicine 155, 549–553.Google Scholar
Wilkinson, D. I. & Karasek, M. A. (1966). Skin lipids of a normal and a mutant (Asebic) mouse strain. Journal of Investigative Dermatology 47, 449–455.Google Scholar