Skip to main content Accessibility help
×
Home

Selection of new inversions in multi-locus genetic systems

  • Brian Charlesworth (a1) and Deborah Charlesworth (a1)

Summary

An approximate expression, is derived for the rate of change in frequency of an inversion introduced at a low initial frequency into a multi-locus system at equilibrium under recombination and selection. It is shown that this expression gives accurate predictions of the rate of progress of the inversion, even if the initial population is perturbed somewhat from equilibrium. Extensions to the cases where there are sex differences in recombination and selection are considered. An implication of the results is that selection pressure for newly arisen inversions depends on the existence of a stable equilibrium with linkage disequilibrium. The expected chance of survival of a new inversion in a large population is shown to be approximately one half the square root of the loss in fitness due to recombination.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Selection of new inversions in multi-locus genetic systems
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Selection of new inversions in multi-locus genetic systems
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Selection of new inversions in multi-locus genetic systems
      Available formats
      ×

Copyright

References

Hide All
Bodmer, W. F. & Felsenstein, J. (1967). Linkage and selection: theoretical analysis of the deterministic two locus random mating model. Genetics 57, 237265.
Deakin, M. A. B. (1972). A model for inversion polymorphism. Journal of Theoretical Biology 35, 191212.
Dobzhausky, T. (1951). Genetics and the Origin of Species. New York: Columbia University Press.
Dobzhansky, T. (1970). The Genetics of the Evolutionary Process. New York: Columbia University Press.
Feldman, M. W. (1972). Selection for linkage modification: 1. Random mating populations. Theoretical Population Biology 3, 324346.
Fisher, R. A. (1930). The Genetical Theory of Natural Selection. Oxford: Clarendon Press.
Fraser, A. S. & Burnell, D. (1967). Simulation of genetic systems. XI. Inversion polymorphism. American Journal of Human Genetics 19, 270286.
Geirnger, H. (1948). On the mathematics of random mating in case of different recombination values for males and females. Genetics 33, 548554.
Haldane, J. B. S. (1957). The conditions for co-adaptation in polymorphism for inversions. Journal of Genetics 55, 218225.
Kimura, M. (1956). A model of a system which leads to closer linkage by natural selection. Evolution 9, 419435.
Kojima, K. (1967). Likelihood of establishing newly induced inversion chromosomes in small populations. Ciencia e Cultura 19, 6777.
Kojima, K. & Kelleher, T. M. (1961). Changes of mean fitness in random mating populations when epistasis and linkage are present. Genetics 46, 527540.
Kojima, K. & Klekar, A. (1969). Deterministic simulation of evolutionary changes in three-locus genetic systems. In Computer Applications in Genetics, ed. Morton, N. E., pp. 147160. Honolulu: University of Hawaii Press.
Lewontin, R. C. (1964). The interaction of selection and linkage. I. General considerations; heterotic models. Genetics 49, 4967.
Lewontin, R. C. (1971). The effect of genetic linkage on the mean fitness of a population. Proceedings of the National Academy of Sciences, U.S.A. 68, 984986.
Lewontin, R. C. & Kojima, K. (1960). The evolutionary dynamics of complex polymorphisms. Evolution 14, 458472.
Nei, M. (1967). Modification of linkage intensity by natural selection. Genetics 57, 625641.
Nei, M., Kojima, K. & Schaffer, H. (1967). Frequency changes of new inversions in populations under mutation-selection equilibria. Genetics 57, 741750.
Ohta, T. (1971). Associative overdominance caused by linked detrimental mutations. Genetical Research 18, 227286.
Sperlich, D. (1959). Experimentelle Beiträge zum Problem des positiven Heterosis-effekts bei der struktur-polymorphen Art Drosophila subobscura. Zeitschrift für Vererbungslehre 90, 273287.
Sturtevant, A. H. & Mather, K. (1938). The interrelations of inversions, heterosis and recombination. American Naturalist 72, 447452.
Turner, J. R. G. (1970). Some properties of two locus systems with epistatic selection. Genetics 64, 147155.

Selection of new inversions in multi-locus genetic systems

  • Brian Charlesworth (a1) and Deborah Charlesworth (a1)

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed