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Selection of new inversions in multi-locus genetic systems

Published online by Cambridge University Press:  14 April 2009

Brian Charlesworth  and
Deborah Charlesworth
Brian Charlesworth
Affiliation:
Department of Genetics, University of Liverpool, Liverpool, L69 3BX
Deborah Charlesworth
Affiliation:
Department of Genetics, University of Liverpool, Liverpool, L69 3BX
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Summary

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An approximate expression, is derived for the rate of change in frequency of an inversion introduced at a low initial frequency into a multi-locus system at equilibrium under recombination and selection. It is shown that this expression gives accurate predictions of the rate of progress of the inversion, even if the initial population is perturbed somewhat from equilibrium. Extensions to the cases where there are sex differences in recombination and selection are considered. An implication of the results is that selection pressure for newly arisen inversions depends on the existence of a stable equilibrium with linkage disequilibrium. The expected chance of survival of a new inversion in a large population is shown to be approximately one half the square root of the loss in fitness due to recombination.

Type
Research Article
Information
Genetics Research , Volume 21 , Issue 2 , April 1973 , pp. 167 - 183
Copyright
Copyright © Cambridge University Press 1973

References

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