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Search for differences among t haplotypes in distorter and responder genes

Published online by Cambridge University Press:  14 April 2009

Mary F. Lyon
Mary F. Lyon
Affiliation:
MRC Radiobiology Unit, Chilton, Didcot, Oxon OX11 ORD, UK
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Transmission ratio distortion due to the mouse t complex is thought to be due to harmful effects of trans-acting distorter genes acting on a responder, with the t complex form of the responder being relatively resistant to this harmful action of the distorters. Previous work had indicated that naturally occurring t haplotypes differed in their responders or in distorters lying near the responder, with the result that animals doubly heterozygous for two responder-carrying haplotypes transmitted these haplotypes unequally. In the present work t haplotypes could be divided into three types on the basis of their transmission when doubly heterozygous with the responder-carrying partial haplotype tlowH. The majority, t0, t6, tw1, tw2 and tw73, were transmitted equally with tlowH, a second group, including tw5 and two haplotypes derived from it, were transmitted less frequently than tlowH, and the single member of a third group, t32, was transmitted in excess of tlowH This last result suggests that the underlying differences are in the responder itself, rather than in the distorters. Search for differences among t haplotypes in distorters produced some equivocal results possibly resulting from effects of genetic background. In particular, results of others suggesting presence of a fourth distorter, Tcd-4, were not confirmed.

Type
Research Article
Information
Genetics Research , Volume 55 , Issue 1 , February 1990 , pp. 13 - 19
Copyright
Copyright © Cambridge University Press 1990

References

Artzt, K., Shin, H.-S. & Bennett, D. (1982). Gene mapping within the T/t complex of the mouse. II. Anomalous position of the H-2 complex in t haplotypes. Cell 28, 471–476.CrossRefGoogle Scholar
Bennett, D. (1975). The T-locus of the mouse. Cell 6, 441–454.CrossRefGoogle Scholar
Bennett, D., Alton, A. K. & Artzt, K. (1983). Genetic analysis of transmission ratio distortion by t haplotypes in the mouse. Genetical Research 41, 29–45.CrossRefGoogle Scholar
Dooher, G. B. & Bennett, D. (1977). Spermiogenesis and spermatozoa in sterile mice carrying different lethal T/t locus haplotypes, a transmission and scanning electron microscopic study. Biology of Reproduction 17, 269–288.CrossRefGoogle ScholarPubMed
Fox, H. S., Martin, G. R., Lyon, M. F., Herrmann, B., Frischauf, A.-M., Lehrach, H. & Silver, L. M. (1985). Molecular probes define different regions of the mouse t complex. Cell 40, 63–69.CrossRefGoogle ScholarPubMed
Frischauf, A. M. (1985). The T/t complex of the mouse. Trends in Genetics 1, 100–103.CrossRefGoogle Scholar
Gummere, G. R., McCormick, P. J. & Bennett, D. (1986). The influence of genetic background and the homologous chromosome 17 on t-haplotype transmission ratio distortion in mice. Genetics 114, 235–245.CrossRefGoogle ScholarPubMed
Hammer, M. F., Schimenti, J. & Silver, L. M. (1989). Evolution of mouse chromosome 17 and the origin of inversions associated with t haplotypes. Proceedings of the National Academy of Sciences, U.S.A. 86, 3261–3265.CrossRefGoogle ScholarPubMed
Hammerberg, C. (1982). The effects of the t complex upon male reproduction are due to complex interactions between its several regions. Genetical Research 39, 219–226.CrossRefGoogle Scholar
Herrmann, B., Bućan, M., Mains, P., Frischauf, A.-M., Silver, L. M. & Lehrach, H. (1986). Genetic analysis of the proximal portion of the mouse t complex: evidence for a second inversion within t haplotypes. Cell 44, 469–476.CrossRefGoogle Scholar
Herrmann, B. G., Barlow, D. P. & Lehrach, H. (1987). A large inverted duplication allows homologous recombination between chromosomes heterozygous for the proximal t complex inversion. Cell 48, 813–825.CrossRefGoogle ScholarPubMed
Klein, J., Sipos, P. & Figueroa, F. (1984). Polymorphism of t-complex genes in European wild mice. Genetical Research 44, 39–46.CrossRefGoogle Scholar
Lewontin, R. C. (1962). Interdeme selection controlling a polymorphism in the house mouse. American Naturalist 96, 65–78.CrossRefGoogle Scholar
Lewontin, R. C. (1968). The effect of differential viability on the population dynamics of t alleles in the house mouse. Evolution 22, 262–273.CrossRefGoogle ScholarPubMed
Lewontin, R. C. & Dunn, L. C. (1960). The evolutionary dynamics of a polymorphism in the house mouse. Genetics 45, 705–722.CrossRefGoogle ScholarPubMed
Lyon, M. F. (1984). Transmission ratio distortion in mouse t haplotypes is due to multiple distorter genes acting on a responder locus. Cell 37, 621–628.CrossRefGoogle ScholarPubMed
Lyon, M. F. (1986). Male sterility of the mouse t complex is due to homozygosity of the distorter genes. Cell 44, 357–363.CrossRefGoogle Scholar
Lyon, M. F. (1989). The genetic basis of transmission ratio distortion and male sterility due to the mouse t complex. American Naturalist (in the press).Google Scholar
Lyon, M. F. & Meredith, R. (1964). Investigation of the nature of t alleles in the mouse. II. Genetic analysis of an unusual mutant allele and its derivatives. Heredity 19, 313–325.CrossRefGoogle ScholarPubMed
Lyon, M. F. & Zenthon, J. (1987). Differences in or near the responder region of complete and partial mouse t haplotypes. Genetical Research 50, 29–34.CrossRefGoogle ScholarPubMed
Rappold, G. A., Stubbs, L., Labeit, S., Crkvenjakov, R. B. & Lehrach, H. (1987). Identification of a testis-specific gene from the mouse t complex next to a CpG-rich island. EMBO Journal 6, 1975–1980.CrossRefGoogle Scholar
Schimenti, J., Cebra-Thomas, J. A., Decker, C. L., Islam, S. D., Pilder, S. H. & Silver, L. M. (1988). A candidate gene family for the mouse t complex responder (Tcr) locus responsible for haploid effects on sperm function. Cell 55, 71–78.CrossRefGoogle Scholar
Shin, H. S., Flaherty, L., Artzt, K., Bennett, D. & Ravetch, J. (1983). Inversion in the H-2 complex of t haplotypes in mice. Nature 306, 380–383.CrossRefGoogle ScholarPubMed
Silver, L. M. (1985). Mouse t haplotypes. Annual Review of Genetics 19, 179–208.CrossRefGoogle ScholarPubMed
Silver, L. M. & Remis, D. (1987). Five of the nine genetically defined regions of mouse t haplotypes are involved in transmission ratio distortion. Genetical Research 49, 51–56.CrossRefGoogle ScholarPubMed