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A presumed deletion covering the W and Ph loci of the mouse

Published online by Cambridge University Press:  14 April 2009

Mary F. Lyon ,
P. H. Glenister ,
J. F. Loutit ,
E. P. Evans  and
J. Peters
Mary F. Lyon
Affiliation:
MRC Radiobiology Unit, Harwell, Didcot, Oxon OX11 0RD, England
P. H. Glenister
Affiliation:
MRC Radiobiology Unit, Harwell, Didcot, Oxon OX11 0RD, England
J. F. Loutit
Affiliation:
MRC Radiobiology Unit, Harwell, Didcot, Oxon OX11 0RD, England
E. P. Evans
Affiliation:
MRC Radiobiology Unit, Harwell, Didcot, Oxon OX11 0RD, England
J. Peters
Affiliation:
MRC Radiobiology Unit, Harwell, Didcot, Oxon OX11 0RD, England

Summary

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A new allele at the W-locus ( W19H), found in a mutagenesis experiment in which females were irradiated, involves a presumed deletion. The deletion covers the Ph locus (which forms part of a gene complex with the W, Ph and Rw loci), and the locus of a recessive lethal 2 cM distal to W. It does not extend distally to the bl locus; nor does it involve the Rw locus, W19H/Rw compounds being viable and fertile. Thus, the length of the deletion is 2–7 cM. The non-involvement of Rw shows that, in the gene triplet Rw, W, Ph, Rw must lie proximal to W and Ph, whose relative position remains unknown. Heteozygotes for W19H are not anaemic, show only minimal white spotting and no pigment dilution; they thus resemble heterozygotes for the original W mutant allele and differ from W/Ph trans heterozygotes, which have extensive white spotting. In addition W19H heterozygotes may be small and runted, many are believed to die prenatally, and some in the nest. Their radiosensitivity is increased. Homozygotes die at the pre-implantation stage.

Type
Research Article
Information
Genetics Research , Volume 44 , Issue 2 , October 1984 , pp. 161 - 168
Copyright
Copyright © Cambridge University Press 1984

References

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