Molecular correlates of the murine Xce locus

PHILIP AVNER; MARINE PRISSETTE; DANIELLE ARNAUD; BÉATRICE COURTIER; CHIARA CECCHI; EDITH HEARD

doi:10.1017/S0016672398003516

Abstract

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The murine Xce locus, first identified by Bruce Cattanach, infiuences the primary choice of the X chromosome to be inactivated. Methylation of a GC-rich region (DXPas34) that includes multiple 34 bp repeats and lies some 15 kb 3′ to Xist has been shown to vary with Xce haplotype. The degree of methylation on the active X chromosome at this locus represents one of the few molecular correlates of Xce action currently available. Data relating to the specificity and other characteristics of this association are presented.

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