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A method for detecting effect of beneficial mutations in natural populations of Drosophila melanogaster

Published online by Cambridge University Press:  14 April 2009

A. Koga ,
S. Kusakabe ,
F. Tajima ,
T. Takano ,
K. Harada  and
T. Mukai
A. Koga*
Affiliation:
Department of Biology, Faculty of Science, Kyushu University, Fukuoka 812, Japan
S. Kusakabe
Affiliation:
Department of Biology, Faculty of Science, Kyushu University, Fukuoka 812, Japan
F. Tajima
Affiliation:
Department of Biology, Faculty of Science, Kyushu University, Fukuoka 812, Japan
T. Takano
Affiliation:
Department of Biology, Faculty of Science, Kyushu University, Fukuoka 812, Japan
K. Harada
Affiliation:
Department of Biology, Faculty of Science, Kyushu University, Fukuoka 812, Japan
T. Mukai
Affiliation:
Department of Biology, Faculty of Science, Kyushu University, Fukuoka 812, Japan
*
* Corresponding author.

Summary

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An experimental method is proposed for detecting the effects of positive natural selection on DNA polymorphisms. Since beneficial mutations are expected to increase in frequency faster than neutral mutations, variants which have reached high frequencies in a relatively short period could be linked to some beneficial mutation. D. melanogaster has a cosmopolitan polymorphic inversion -In(2L)t - whose age in some local populations has been estimated. Setting the age of In(2L)t as the upper limit for the age of variants, we searched for variants whose frequencies were possibly influenced by positive natural selection. We detected a single candidate whose frequency and distribution met the requirements imposed by our method.

Type
Research Article
Information
Genetics Research , Volume 58 , Issue 2 , October 1991 , pp. 145 - 156
Copyright
Copyright © Cambridge University Press 1991

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