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Loss of heterozygosity at the dilute–short ear (Myo5a–Bmp5) region of the mouse: mitotic recombination or double non-disjunction?

Published online by Cambridge University Press:  01 December 1998

JACK FAVOR  and
ANGELIKA NEUHÄUSER-KLAUS
JACK FAVOR
Affiliation:
Institute of Mammalian Genetics, GSF-National Research Centre for Environment and Health, Ingolstädter Landstrasse 1, D-85764 Neuherberg, Germany
ANGELIKA NEUHÄUSER-KLAUS
Affiliation:
Institute of Mammalian Genetics, GSF-National Research Centre for Environment and Health, Ingolstädter Landstrasse 1, D-85764 Neuherberg, Germany

Abstract

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The occurrence of homozygous-viable dilute–short ear (Myo5a–Bmp5) double mutants in mouse specific locus mutation experiments has generally been assumed to be the result of double non- disjunction such that the mutant inherits two copies of chromosome 9 carrying the recessive alleles from the test-stock. A homozygous viable Myo5a–Bmp5 double mutant was recovered recently in our laboratory. We were able to genetically analyse both the Myo5a–Bmp5 region and proximal and distal markers in the original mutant as well as in offspring of the original mutant. Our results indicate the mutational event to be due to mitotic recombination and not double non-disjunction.

Type
Research Article
Information
Genetics Research , Volume 72 , Issue 3 , December 1998 , pp. 199 - 204
Copyright
© 1998 Cambridge University Press

Footnotes

For Bruce Cattanach on the occasion of his retirement in appreciation of his many contributions to mouse genetics and mammalian germ cell mutagenesis.