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Linkage of loci associated with two pigment mutations on mouse chromosome 13

Published online by Cambridge University Press:  14 April 2009

Randall F. Holcombe ,
Dennis A. Stephenson ,
Alfred Zweidler ,
Ruby M. Stewart ,
Verne M. Chapman  and
J. G. Seidman
Randall F. Holcombe*
Affiliation:
Department of Medicine, LSU Medical Center, Shreveport, LA 71130 Department of Genetics, Harvard Medical School, Boston, MA 02115
Dennis A. Stephenson
Affiliation:
Department of Molecular and Cellular Biology, Roswell Park Memorial Institute, Buffalo, NY 14263
Alfred Zweidler
Affiliation:
Fox Chase Cancer Center, Philadelphia, PA 19111
Ruby M. Stewart
Affiliation:
Department of Medicine, LSU Medical Center, Shreveport, LA 71130
Verne M. Chapman
Affiliation:
Department of Molecular and Cellular Biology, Roswell Park Memorial Institute, Buffalo, NY 14263
J. G. Seidman
Affiliation:
Department of Genetics, Harvard Medical School, Boston, MA 02115
*
* Corresponding author.

Summary

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Progeny from one intra- and two inter-specific backcrosses between divergent strains of mice were typed to map multiple markers in relation to two pigment mutations on mouse chromosome 13, beige (bg) and pearl (pe). Both recessive mutants on a C57BL/6J background were crossed separately with laboratory strain PAC (M. domesticus) and the partially inbred M. musculus stock PWK. The intra- and inter-specific F1 hybrids were backcrossed to the C57BL/6J parental strain and DNA was prepared from progeny. Restriction fragment length polymorphisms were used to follow the segregation of alleles in the backcross offspring at loci identified with molecular probes. The linkage analysis defines the association between the bg and pe loci and the loci for the T-cell receptor γ-chain gene (Tcrg), the spermatocyte specific histone gene (Hist 1), the prolactin gene (Prl), the Friend murine leukaemia virus integration site 1 (Fim-1), the murine Hanukuh Factor gene (Muhf/Ctla-3) and the dihydrofolate reductase gene (Dhfr). This data confirms results of prior chromosomal mapping studies utilizing bg as an anchor locus, and provides previously unreported information defining the localization of the prolactin gene on mouse chromosome 13. The relationship of multiple loci in relation to pe is similarly defined. These results may help facilitate localization of the genes responsible for two human syndromes homologous with bg and pe, Chediak–Higashi syndrome and Hermansky–Pudlak syndrome.

Type
Research Article
Information
Genetics Research , Volume 58 , Issue 1 , August 1991 , pp. 41 - 50
Copyright
Copyright © Cambridge University Press 1991

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