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Length of the chromosomal segment marked by galactose-1-phosphate uridyl transferase and soluble aconitase and conserved since divergence of lineages leading to mouse and man

Published online by Cambridge University Press:  14 April 2009

Joseph H. Nadeau
Joseph H. Nadeau
Affiliation:
The Jackson Laboratory, Bar Harbor, Maine 04609

Summary

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Standard linkage testing crosses and ovarian teratoma mapping were used to estimate the length of the chromosomal segment that is marked by galactose-1-phosphate uridyl transferase and soluble aconitase and that has been conserved since divergence of lineages leading to mouse and man. These experiments were also used to determine whether the Rb(4·6)2Bnr Robertsonian translocation suppresses recombination on the proximal portion of mouse Chromosome 4. The estimated length of the conserved segment marked by galactose-1-phosphate uridyl transferase and soluble aconitase in mouse and man was estimated to be 24 cM. It was also shown that Rb(4·6)2Bnr strongly suppressed recombination on the centromeric portion of mouse Chromosome 4.

Type
Research Article
Information
Genetics Research , Volume 52 , Issue 2 , October 1988 , pp. 141 - 144
Copyright
Copyright © Cambridge University Press 1988

References

Aitken, D. A. & Ferguson-Smith, M. A. (1979). Intra-chromosomal assignment of the structural gene for GALT to the short arm of chromosome 9 by gene dosage studies. Cytogenetics and Cell Genetics 25, 131.Google Scholar
Baumann, H & Berger, F. G. (1985). Genetics and evolution of the acute phase reactant proteins in mice. Molecular and General Genetics 201, 505–512.Google Scholar
Baumann, H., Held, W. A. & Berger, F. G. (1984). The acute phase response of mouse liver; genetic analysis of the major acute phase reactants. Journal of Biological Chemistry 259, 566–573.Google Scholar
Bruns, G. A. P., Leary, A. C., Eisenman, R. E., Bazinet, C. W., Regina, V. M. & Gerald, P. S. (1978). Expression of ACON s and GALT in man-rodent somatic cell hybrids. Cytogenetics and Cell Genetics 22, 172–176.Google Scholar
Cattanach, B. M. (1978). Crossover suppression in mice heterozygous for tobacco mouse metacentrics. Cytogenetics and Cell Genetics 20, 264–281.CrossRefGoogle ScholarPubMed
Collins, R. L. (1970). A new genetic locus mapped from behavioral variation in mice: audiogenic seizure prone (asp). Behavioral Genetics 1, 99–109.Google Scholar
Cook, P. J. L., Robson, E. B., Buckton, K. E., Slaughter, C. A., Gray, J. E., Blank, C. E., James, F. E., Ridler, M. A. C., Insley, J. & Hulten, M. (1978). Segretation of ABO, AKl, and ACONS in families with abnormalities of chromosome 9. Annals of Human Genetics 41, 365–376.Google Scholar
DeMaeyer, E. & Dandoy, F. (1987). Linkage analysis of the murine interferon alpha locus (Ifa) on chromosome 4. Journal of Heredity 78, 143–146.Google Scholar
Eiberg, H., Mohr, J. & Staub-Nielsen, L. (1982). Linkage of orosomucoid (ORM) and ABO and AKl. Cytogenetics and Cell Genetics 32, 272.Google Scholar
Eiberg, H., Mohr, J. & Staub-Nielsen, L. (1983). Delta-amino-levulinate dehydratase: synteny with ABO-AKl-ORM (and assignment to chromosome 9). Clinical Genetics 23, 150–154.CrossRefGoogle Scholar
Eicher, E. M. (1978). Murine ovarian teratomas and parthenotes as cytogenetic tools. Cytogenetics and Cell Genetics 20, 232–239.Google Scholar
Eppig, J. T. & Eicher, E. M. (1983). Application of the ovarian teratoma mapping method in the mouse. Genetics 103, 797–812.Google Scholar
Lusis, A. J., Taylor, B. A., Quon, D., Zollman, S. & LeBoeuf, R. C. (1987). Genetic factors controlling the structure and expression of apolipoproteins B & E in mice. Journal of Biological Chemistry 262; 7594–7604.CrossRefGoogle ScholarPubMed
Mohandas, T., Sparkes, R. S., Shulkin, J. D., Toomey, K. E. & Funderburk, S. J. (1979). Regional localization of human gene loci on chromosome 9: studies of somatic cell hybrids containing human translocations. American Journal of Human Genetics 31, 586–600.Google Scholar
Mohandas, T., Sparkes, R. S., Sparkes, M. C. & Shulkin, J. D. (1977). Assignment of the human gene for galactose-1-phosphate uridyl transferase to chromosome 9: studies with Chinese hamster-human somatic cell hybrids. Proceedings of the National Academy of Sciences USA 74, 5628–5631.Google Scholar
Mulcahy, M. T. & Wilson, R. G. (1980). Where is the gene for GALT? Human Genetics 54, 129–130.CrossRefGoogle ScholarPubMed
Nadeau, J. H., Berger, F. G., Kelley, K. A., Pitha, P. M., Sidman, C. L. & Worrall, N. (1986). Rearrangement of genes located on homologous chromosomal segments in mouse and man: the location of genes for alpha- and beta-interferon, alpha-1 acid glycoprotein-1 and -2, and aminolevulinate dehydratase on mouse Chromosome 4. Genetics 104, 1239–1255.CrossRefGoogle Scholar
Nadeau, J. H. & Eicher, E. M. (1982). Conserved linkage of soluble aconitase and galactose-1-phosphate uridyl transferase in mouse and man: assignment of these genes to mouse chromosome 4. Cytogenetics and Cell Genetics 34, 271–281.Google Scholar
Nadeau, J. H. & Reiner, A. H. (1988). Linkage and synteny homologies in mouse and man. In Genetic Variants and Strains of the Laboratory Mouse (ed. Lyon, M. F. & Searle, A. G.). Oxford: Oxford University Press (in press).Google Scholar
Nadeau, J. H. & Taylor, B. A. (1984). Lengths of chromosomal segments conserved since divergence of man and mouse. Proceedings of the National Academy of Sciences USA 81, 814–818.Google Scholar
Ott, J., Linder, D., McCaw, K., Lovrien, E. W. & Hecht, F. (1976). Estimating distances from the centromere by means of benign ovarian teratomas in man. Annals of Human Genetics 40, 191–196.Google Scholar
Seyfried, T. N. & Glaser, G. H., (1981). Genetic linkage between the Ah locus and a major gene that inhibits susceptibility to audiogenic seizures in mice. Genetics 99, 117–126.Google Scholar
Smith, M. & Spence, M. A. (1985). Report of the committee on the genetic constituion of chromosomes 7, 8, and 9. Cytogenetics and Cell Genetics 40, 156–178.Google Scholar
Westerveld, A., Beyersberger van Henegouwen, H. M. A. & van Someren, H. (1975). Evidence for synteny between the human loci for galactose-1-phosphate uridyl transferase and aconitase in man-Chinese hamster somatic cell hybrids. Cytogenetics and Cell Genetics 14, 283–284.Google Scholar