Hostname: page-component-848d4c4894-8kt4b Total loading time: 0 Render date: 2024-07-04T05:47:04.084Z Has data issue: false hasContentIssue false

Immunogenetics of an antigen identified in both sheep and cattle sera

Published online by Cambridge University Press:  14 April 2009

Giovanna De Benedictis
Affiliation:
Department of Cellular Biology, University of Calabria, Arcavacata (CS), Italy
P. Capalbo
Affiliation:
Department of Cellular Biology, University of Calabria, Arcavacata (CS), Italy
E. Gallina
Affiliation:
Department of Cellular Biology, University of Calabria, Arcavacata (CS), Italy

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Alloimmunization in sheep revealed an antigen specificity B1 which is also to be found in cattle sera. The molecular weight of the protein carrying B1 was greater in sheep than in cattle, whilst in both cases its isoelectric point was at pH 6·2. The electrophoretic position of the antigen suggests that the molecule carrying B1 might be a β-globulin. Family studies indicated that in both species B1 was inherited in a simple Mendelian manner, as if it were a product of a dominant allele B1 at an autosomal locus B.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1979

References

REFERENCES

Bash, J. A. & Milgrom, F. (1972). Studies of allotypes in sheep. International Archives of Allergy 42, 196.CrossRefGoogle ScholarPubMed
Blakeslee, D., Butler, J. E. & Stone, W. H. (1971). Serum antigens of cattle. Immunogenetics of two immunoglobulin allotypes. Journal of Immunology 107, 207.Google ScholarPubMed
Curtain, C. C. (1971). Allotypes of serum α2 macroglobulin, β lipo protein and γ immunoglobulin in the domesticated sheep (Ovis aries). Vox Sanguinis 21, 372.Google Scholar
De Benedictis, G. (1979). Immunochemistry of two polymorphic antigens identified in sheep serum (Ovis aries). International Journal of Immunochemistry (now Molecular Immunology) 16, 347.Google ScholarPubMed
Feinstein, A., Gell, P. G. H. & Kelus, A. S. (1963). Immunochemical analysis of rabbit gammaglobulin allotypes. Nature 4907, 653.CrossRefGoogle Scholar
Goldstein, I. J. & Iyer, R. N. (1966). Interaction of ConcanavalinA, a phytohemagglutinin, with model substrates. Biochemical and Biophysical Acta 121, 197.CrossRefGoogle Scholar
Harris, M. & Robson, E. B. (1963). Precipitin reactions between extracts of seeds of Canavalia ensiformis (jack bean) and normal and pathological serum proteins. Vox Sanguinis 8, 348.Google ScholarPubMed
Iannelli, D. (1978 a). Immunogenetics of a sheep (Ovis aries) serum antigen. Genelical Research 31, 209.CrossRefGoogle ScholarPubMed
Iannelli, D. (1978 b). Water buffalo (Bubalus bubalus Arnee) allotypes: identification of a multiple allelic system. Animal Blood Groups and Biochemical Genetics 9, 105.CrossRefGoogle ScholarPubMed
Iannelli, D. (1969). A serum antigen detected in cattle by microimmuno diffusion. Experientia 25, 423.CrossRefGoogle Scholar
Iannelli, D. & De Benedictis, G. (1978). Molecular localization of two cattle allotypic specificities. Biochemical and Biophysical Research Communications 82, 887.CrossRefGoogle ScholarPubMed
Iannelli, D., Oreste, U., Masina, P., De Benedictis, G. & Cianfrigua, M. (1978) Genetics of a low density lipoprotein allotype in cattle. Animal Blood Grovps and Biochemical Genetics 9, 21.CrossRefGoogle Scholar
Rapacz, J., Hasler, J. & Pope, A. L. (1970). Lipoprotein serum antigen in sheep. Proceedings 12th International Animal Blood Groups and Biochemical Polymorphism, Budapest, Hungary.Google Scholar
Rapacz, J., Korda, N. & Stone, W. H. (1968). Serum antigens of cattle. Immunogenetics of a macroglobulin allotype. Genetics 58, 387.CrossRefGoogle ScholarPubMed
Steinberg, A. G. (1967). Genetic variations of human immunoglobulins. The Gm and Inv types: In Greenwalt, Advances in Immunogenetics, p. 75, Philadelphia: Lippincott.Google Scholar