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Genetical studies on the skeleton of the mouse XXIX. Pudgy

Published online by Cambridge University Press:  14 April 2009

Hans Grüneberg
Hans Grüneberg
Affiliation:
Experimental Genetics Research Unit (Medical Research Council) University College, London
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The recessive mutant pudgy in the mouse has a greatly shortened vertebral column with highly irregular fusions between vertebrae and fragments of vertebrae. Ribs and sternum are also involved, but the rest of the skeleton is quite normal. The deformities arise from a defective segmentation. Although the paraxial mesoderm forms somite tissue with an epithelially arranged outer layer, this material either shows only an abortive segmentation into somites or, in the tail, none at all. A belated segmentation into dermomyotomes ultimately takes place, but the sclerotomic material remains continuous and gives rise to erratically abnormal blastemata which then chondrify and ultimately ossify.

Type
Research Article
Information
Genetics Research , Volume 2 , Issue 3 , November 1961 , pp. 384 - 393
Copyright
Copyright © Cambridge University Press 1961

References

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